Mst1r macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mst1rprovided by MGI
Official Full Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)provided by MGI
Primary source: MGI:MGI:99614
See related: Ensembl:ENSMUSG00000032584 AllianceGenome:MGI:99614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fv2; Ron; STK; Fv-2; PTK8; CD136; CDw136; p185-Ron
Summary: This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression: Biased expression in stomach adult (RPKM 26.6), colon adult (RPKM 26.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 59.07 cM; 9 F1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107784057..107797582)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107906858..107920383)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence.
Title: RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence.
RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma.
Title: RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma.
Prostate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression.
Title: Prostate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression.
Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer.
Title: Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer.
c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells.
Title: c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells.
The results demonstrate the protective effects of Ron receptor activation on nonalcoholic steatohepatitis-induced hepatic fibrosis.
Title: Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model.
this study demonstrates neuroprotective role of the Ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Title: Neuroprotective Role of the Ron Receptor Tyrosine Kinase Underlying Central Nervous System Inflammation in Health and Disease.
RON has a role in cancer-induced bone destruction and osteoporosis
Title: RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis.
this study shows that Ron is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1
Title: The Ron Receptor Tyrosine Kinase Regulates Macrophage Heterogeneity and Plays a Protective Role in Diet-Induced Obesity, Atherosclerosis, and Hepatosteatosis.
Report Ron receptor-dependent gene regulation of inflammatory/anti-inflammatory gene expression in Kupffer cells during endotoxemia.
Title: Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Spontaneous (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB542156 (e-PCR)
- UniSTS:208448

PMC34588P1 (e-PCR)
- UniSTS:273225

X74736 (e-PCR)
- UniSTS:125837

PMC115033P1 (e-PCR)
- UniSTS:270283

Mst1r (e-PCR), detects polymorphism
- UniSTS:144354

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: macrophage-stimulating protein receptor

Names: MSP receptor; friend virus susceptibility 2; receptor protein tyrosine kinase, c-met-related; stem cell-derived tyrosine kinase

NP_001274190.1

EC 2.7.10.1

NP_001400491.1

EC 2.7.10.1

NP_033100.2

EC 2.7.10.1

XP_006511717.1

EC 2.7.10.1

XP_006511718.1

EC 2.7.10.1

XP_006511721.1

EC 2.7.10.1

XP_017168707.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287261.2 → NP_001274190.1 macrophage-stimulating protein receptor isoform 2

Status: VALIDATED

Source sequence(s)

AL731808

Conserved Domains (1) summary

cl21453
Location:162 → 423

PKc_like; Protein Kinases, catalytic domain
NM_001413562.1 → NP_001400491.1 macrophage-stimulating protein receptor isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL731808
NM_009074.3 → NP_033100.2 macrophage-stimulating protein receptor isoform 1 preproprotein

See identical proteins and their annotated locations for NP_033100.2

Status: VALIDATED

Source sequence(s)

AL731808

Consensus CDS

CCDS23509.1

UniProtKB/Swiss-Prot

E9QMZ4, Q62190, Q62555

UniProtKB/TrEMBL

B2RUR6

Related

ENSMUSP00000035203.8, ENSMUST00000035203.9

Conserved Domains (7) summary

cd11279
Location:29 → 525

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:771 → 863

IPT; ig-like, plexins, transcription factors

cd01179
Location:686 → 770

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1063 → 1324

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:528 → 567

PSI; Plexin repeat

pfam07714
Location:1059 → 1315

Pkinase_Tyr; Protein tyrosine kinase

cl15674
Location:571 → 685

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RNA

NR_109782.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL731808

Related

ENSMUST00000195617.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

107784057..107797582

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511654.4 → XP_006511717.1 macrophage-stimulating protein receptor isoform X1

UniProtKB/TrEMBL

B2RUR6

Conserved Domains (6) summary

cd11279
Location:29 → 525

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00423
Location:528 → 570

PSI; domain found in Plexins, Semaphorins and Integrins

smart00429
Location:771 → 864

IPT; ig-like, plexins, transcription factors

cd01179
Location:686 → 770

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cl15674
Location:571 → 685

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl21453
Location:1064 → 1352

PKc_like; Protein Kinases, catalytic domain
XM_006511655.4 → XP_006511718.1 macrophage-stimulating protein receptor isoform X2

UniProtKB/TrEMBL

B2RUR6

Conserved Domains (6) summary

cd11279
Location:29 → 525

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00423
Location:528 → 570

PSI; domain found in Plexins, Semaphorins and Integrins

smart00429
Location:771 → 863

IPT; ig-like, plexins, transcription factors

cd01179
Location:686 → 770

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cl15674
Location:571 → 685

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl21453
Location:1063 → 1351

PKc_like; Protein Kinases, catalytic domain
XM_006511658.3 → XP_006511721.1 macrophage-stimulating protein receptor isoform X5

Conserved Domains (3) summary

cd11279
Location:29 → 525

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00423
Location:528 → 570

PSI; domain found in Plexins, Semaphorins and Integrins

cl15674
Location:571 → 685

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_017313218.1 → XP_017168707.1 macrophage-stimulating protein receptor isoform X4

Conserved Domains (6) summary

smart00423
Location:99 → 141

PSI; domain found in Plexins, Semaphorins and Integrins

smart00429
Location:342 → 435

IPT; ig-like, plexins, transcription factors

cd01179
Location:257 → 341

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cl15674
Location:142 → 256

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:1 → 96

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

cl21453
Location:635 → 923

PKc_like; Protein Kinases, catalytic domain