St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: St3gal4provided by MGI
Official Full Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 4provided by MGI
Primary source: MGI:MGI:1316743
See related: Ensembl:ENSMUSG00000032038 AllianceGenome:MGI:1316743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Siat4c; SIAT4-C; ST3GalIV; ST3Gal IV
Summary: Enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in positive regulation of blood coagulation and positive regulation of leukocyte tethering or rolling. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi cisterna membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Orthologous to human ST3GAL4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in large intestine adult (RPKM 32.7), small intestine adult (RPKM 23.8) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 19.36 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (34957872..35028160, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (35046576..35116864, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.
Title: CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.
Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
Title: Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
The results of this study indicated that ST3Gal IV is a key molecule in the mechanisms underlying anxiety - a side effect of TLE - and may therefore also be an effective target for treating epilepsy, acting through the same circuits.
Title: Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
St3Gal4-deficient myeloid cells had less binding of Ccl5 and impaired Ccl5-triggered integrin activation. St3Gal4 deficiency reduced the size, stage, and inflammatory cell content of atherosclerotic lesions in Apoe(-/-) mice on high-fat diet.
Title: Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication.
St3gal4, potentially involved in antithrombin sialylation, was 85% lower in neonates in comparison with adults
Title: Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a.
Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction.
Title: Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction.
Coordinated participation of both ST3Gal-VI and ST3Gal-IV in the synthesis of functional selectin ligands.
Title: Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands.
Data show that the sialyltransferase enzymes St6gal1 and St3gal4 are responsible for the production of sialyllactose in mouse milk.
Title: Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization.
Sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo.
Title: Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation.
operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands
Title: Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Siat4c (e-PCR), detects polymorphism
- UniSTS:261914

PMC126621P1 (e-PCR)
- UniSTS:270549

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	IBA Inferred from Biological aspect of Ancestor more info
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	IEA Inferred from Electronic Annotation more info
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	ISO Inferred from Sequence Orthology more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in glycolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid glycosylation	IEA Inferred from Electronic Annotation more info
involved_in lipid glycosylation	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein sialylation	ISO Inferred from Sequence Orthology more info
involved_in sialylation	IEA Inferred from Electronic Annotation more info
involved_in sialylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Names: N-acetyllactosaminide alpha-2,3-sialyltransferase; alpha 2,3-ST 4; alpha 2,3-sialyltransferase IV; beta-galactoside alpha-2,3-sialyltransferase 4; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase; gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase; sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase); sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase)

NP_033204.2

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

XP_006510171.1

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

XP_006510172.1

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

XP_006510173.1

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

XP_006510174.1

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

XP_006510175.1

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

XP_011240731.1

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

XP_011240735.1

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

XP_036010638.1

EC 2.4.3.2

EC 2.4.3.4

EC 2.4.3.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009178.4 → NP_033204.2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

See identical proteins and their annotated locations for NP_033204.2

Status: VALIDATED

Source sequence(s)

AC140448, AI385650, BC050773

Consensus CDS

CCDS22956.1

UniProtKB/Swiss-Prot

P97354, Q61325, Q91Y74

UniProtKB/TrEMBL

Q921R5

Related

ENSMUSP00000034537.7, ENSMUST00000034537.8

Conserved Domains (1) summary

pfam00777
Location:107 → 331

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

34957872..35028160 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154745.1 → XP_036010638.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

UniProtKB/Swiss-Prot

P97354, Q61325, Q91Y74

UniProtKB/TrEMBL

Q921R5

Conserved Domains (1) summary

pfam00777
Location:107 → 331

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006510108.2 → XP_006510171.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X2

UniProtKB/TrEMBL

Q921R5

Conserved Domains (1) summary

pfam00777
Location:147 → 371

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006510109.5 → XP_006510172.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X3

UniProtKB/TrEMBL

Q921R5

Conserved Domains (1) summary

pfam00777
Location:144 → 368

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006510110.5 → XP_006510173.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X4

UniProtKB/TrEMBL

Q921R5

Conserved Domains (1) summary

pfam00777
Location:141 → 365

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_011242429.4 → XP_011240731.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X7

See identical proteins and their annotated locations for XP_011240731.1

UniProtKB/TrEMBL

Q921R5

Conserved Domains (1) summary

pfam00777
Location:139 → 363

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006510112.5 → XP_006510175.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X6

See identical proteins and their annotated locations for XP_006510175.1

UniProtKB/TrEMBL

Q921R5

Conserved Domains (1) summary

pfam00777
Location:139 → 363

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_011242433.2 → XP_011240735.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

See identical proteins and their annotated locations for XP_011240735.1

UniProtKB/Swiss-Prot

P97354, Q61325, Q91Y74

UniProtKB/TrEMBL

Q921R5

Conserved Domains (1) summary

pfam00777
Location:107 → 331

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006510111.4 → XP_006510174.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X5

See identical proteins and their annotated locations for XP_006510174.1

UniProtKB/TrEMBL

Q921R5

Conserved Domains (1) summary

pfam00777
Location:139 → 363

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)