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    RPL15 ribosomal protein L15 [ Homo sapiens (human) ]

    Gene ID: 6138, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPL15provided by HGNC
    Official Full Name
    ribosomal protein L15provided by HGNC
    Primary source
    HGNC:HGNC:10306
    See related
    Ensembl:ENSG00000174748 MIM:604174; AllianceGenome:HGNC:10306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L15; EC45; eL15; DBA12; RPL10; RPLY10; RPYL10
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 335.5), thyroid (RPKM 183.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPL15 in Genome Data Viewer
    Location:
    3p24.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (23916545..23924631)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (23921321..23929407)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23958036..23966122)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19600 Neighboring gene UBE2E1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14144 Neighboring gene ubiquitin conjugating enzyme E2 E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19605 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23906443-23907202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23924271-23924855 Neighboring gene ARF like GTPase 4A pseudogene 4 Neighboring gene NFKB inhibitor interacting Ras like 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:23958136-23959335 Neighboring gene uncharacterized LOC124909354 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:23987327-23987868 Neighboring gene Sharpr-MPRA regulatory region 12700 Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene MPRA-validated peak4577 silencer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Diamond-Blackfan anemia 12
    MedGen: C3809888 OMIM: 615550 GeneReviews: Diamond-Blackfan Anemia
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2014-07-16)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2014-07-16)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26304, MGC88603

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    large ribosomal subunit protein eL15
    Names
    60S ribosomal protein L15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033850.2 RefSeqGene

      Range
      5588..9445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1152

    mRNA and Protein(s)

    1. NM_001253379.2NP_001240308.1  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_001240308.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914, AI886077, BI544251, DA037869
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000483260.1, ENST00000611050.4
      Conserved Domains (1) summary
      pfam00827
      Location:2191
      Ribosomal_L15e; Ribosomal L15
    2. NM_001253380.2NP_001240309.1  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_001240309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914, AI886077, AY347528, DB461802
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000346867.5, ENST00000354811.5
      Conserved Domains (1) summary
      pfam00827
      Location:2191
      Ribosomal_L15e; Ribosomal L15
    3. NM_001253382.2NP_001240311.1  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_001240311.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914, AI886077, BE893727, BU178524
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000493759.1, ENST00000644185.1
      Conserved Domains (1) summary
      pfam00827
      Location:2191
      Ribosomal_L15e; Ribosomal L15
    4. NM_001253383.3NP_001240312.1  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_001240312.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914, DA205054, DC351786
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000416692.1, ENST00000413699.7
      Conserved Domains (1) summary
      pfam00827
      Location:2191
      Ribosomal_L15e; Ribosomal L15
    5. NM_001253384.2NP_001240313.1  large ribosomal subunit protein eL15 isoform 2

      See identical proteins and their annotated locations for NP_001240313.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) includes an alternate exon in the 3' UTR and coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC124914, BC081565, BI544251
      Consensus CDS
      CCDS58818.1
      UniProtKB/TrEMBL
      E7EX53
      Related
      ENSP00000398788.2, ENST00000456530.7
      Conserved Domains (1) summary
      cl02977
      Location:2120
      Ribosomal_L15e; Ribosomal L15
    6. NM_002948.5NP_002939.2  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_002939.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000309334.5, ENST00000307839.10
      Conserved Domains (1) summary
      pfam00827
      Location:2191
      Ribosomal_L15e; Ribosomal L15

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      23916545..23924631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      23921321..23929407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)