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    KIF20B kinesin family member 20B [ Homo sapiens (human) ]

    Gene ID: 9585, updated on 9-Dec-2024

    Summary

    Official Symbol
    KIF20Bprovided by HGNC
    Official Full Name
    kinesin family member 20Bprovided by HGNC
    Primary source
    HGNC:HGNC:7212
    See related
    Ensembl:ENSG00000138182 MIM:605498; AllianceGenome:HGNC:7212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT90; MPP1; KRMP1; MPP-1; MPHOSPH1
    Summary
    Enables several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 5.3), lymph node (RPKM 5.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIF20B in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (89701590..89774934)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (90585487..90658826)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91461347..91534691)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pantothenate kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2594 Neighboring gene PANK1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr10:91453141-91453642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2595 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:91460993-91461508 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:91461509-91462025 Neighboring gene tigger transposable element derived 2 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr10:91500841-91501342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2596 Neighboring gene MT-ND5 pseudogene 42 Neighboring gene uncharacterized LOC105378424 Neighboring gene long intergenic non-protein coding RNA 865

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434B0435, DKFZp434P0810

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables WW domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables plus-end-directed microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitotic cytokinetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic nuclear division NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in contractile ring IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle midzone ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF20B
    Names
    M-phase phosphoprotein 1
    cancer/testis antigen 90
    kinesin-related motor interacting with PIN1
    mitotic kinesin-like protein
    mitotic kinesin-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284259.2NP_001271188.1  kinesin-like protein KIF20B isoform 1

      See identical proteins and their annotated locations for NP_001271188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL157389, AL157400
      Consensus CDS
      CCDS60590.1
      UniProtKB/Swiss-Prot
      A8MXM7, O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q96Q89, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5
      Related
      ENSP00000360793.3, ENST00000371728.8
      Conserved Domains (4) summary
      COG1196
      Location:6291455
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01368
      Location:57477
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:64479
      Kinesin; Kinesin motor domain
      cl19219
      Location:12681357
      DUF342; Protein of unknown function (DUF342)
    2. NM_001382506.1NP_001369435.1  kinesin-like protein KIF20B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL157389, AL157400
      Conserved Domains (4) summary
      COG1196
      Location:5581361
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:14301716
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd01368
      Location:57406
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      cd21786
      Location:529583
      RBD_KIF20B; RAB6 binding domain (RBD) found in kinesin-like protein KIF20B, and similar proteins
    3. NM_016195.4NP_057279.2  kinesin-like protein KIF20B isoform 2

      See identical proteins and their annotated locations for NP_057279.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to isoform 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AL157389, AL157400
      Consensus CDS
      CCDS7407.1
      Related
      ENSP00000260753.4, ENST00000260753.8
      Conserved Domains (4) summary
      COG1196
      Location:6731392
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01368
      Location:57477
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:64479
      Kinesin; Kinesin motor domain
      cl19219
      Location:12281317
      DUF342; Protein of unknown function (DUF342)

    RNA

    1. NR_168374.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL157389, AL157400
    2. NR_168375.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL157389, AL157400

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      89701590..89774934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      90585487..90658826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)