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    RRP9 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [ Homo sapiens (human) ]

    Gene ID: 9136, updated on 9-Dec-2024

    Summary

    Official Symbol
    RRP9provided by HGNC
    Official Full Name
    ribosomal RNA processing 9, U3 small nucleolar RNA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16829
    See related
    Ensembl:ENSG00000114767 MIM:620013; AllianceGenome:HGNC:16829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    U3-55K; RNU3IP2
    Summary
    This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]
    Expression
    Ubiquitous expression in appendix (RPKM 6.7), adrenal (RPKM 6.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RRP9 in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51933429..51941904, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51966348..51974823, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51967445..51975920, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene IQCF5 antisense RNA 1 Neighboring gene IQ motif containing F5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:51935927-51937126 Neighboring gene IQ motif containing F1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51975282-51975930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19921 Neighboring gene poly(ADP-ribose) polymerase family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51990057-51990645 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly(rC) binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    contributes_to U3 snoRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables U3 snoRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in rRNA processing IC
    Inferred by Curator
    more info
    PubMed 
    involved_in rRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of box C/D methylation guide snoRNP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    U3 small nucleolar RNA-interacting protein 2
    Names
    RNA, U3 small nucleolar interacting protein 2
    RRP9 homolog
    RRP9, small subunit (SSU) processome component, homolog
    U3 small nucleolar ribonucleoprotein-associated 55 kDa protein
    U3 snoRNP-associated 55-kDa protein
    ribosomal RNA processing 9, small subunit (SSU) processome component, homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004704.5NP_004695.1  U3 small nucleolar RNA-interacting protein 2

      See identical proteins and their annotated locations for NP_004695.1

      Status: REVIEWED

      Source sequence(s)
      AA465355, AC115284, BC010048
      Consensus CDS
      CCDS2837.1
      UniProtKB/Swiss-Prot
      B2R996, O43818, Q8IZ30
      Related
      ENSP00000232888.6, ENST00000232888.7
      Conserved Domains (2) summary
      cd00200
      Location:139439
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:149197
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      51933429..51941904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449172.1XP_047305128.1  U3 small nucleolar RNA-interacting protein 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      51966348..51974823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348335.1XP_054204310.1  U3 small nucleolar RNA-interacting protein 2 isoform X1