U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ARL2 ARF like GTPase 2 [ Homo sapiens (human) ]

    Gene ID: 402, updated on 9-Dec-2024

    Summary

    Official Symbol
    ARL2provided by HGNC
    Official Full Name
    ARF like GTPase 2provided by HGNC
    Primary source
    HGNC:HGNC:693
    See related
    Ensembl:ENSG00000213465 MIM:601175; AllianceGenome:HGNC:693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARFL2; MRCS1
    Summary
    This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 49.3), fat (RPKM 49.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARL2 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65014160..65022184)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65007423..65015448)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64781632..64789656)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane anchored junction protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64757136-64757663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64763842-64764342 Neighboring gene basic leucine zipper ATF-like transcription factor 2 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3163 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:64773912-64775111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3504 Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene microRNA 6879 Neighboring gene Sharpr-MPRA regulatory region 4003 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 18 Neighboring gene sorting nexin 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4938

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ARL2-SNX15

    Readthrough gene: ARL2-SNX15, Included gene: SNX15

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    located_in lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 2
    Names
    ADP ribosylation factor like GTPase 2
    ADP-ribosylation factor-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199745.2NP_001186674.1  ADP-ribosylation factor-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001186674.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AI631767, BC002530, BG706294, CN338497
      Consensus CDS
      CCDS55770.1
      UniProtKB/Swiss-Prot
      P36404
      Related
      ENSP00000432971.1, ENST00000533729.1
      Conserved Domains (2) summary
      cd04154
      Location:3148
      Arl2; Arf-like 2 (Arl2) GTPase
      COG1100
      Location:13120
      Gem1; GTPase SAR1 family domain [General function prediction only]
    2. NM_001667.4NP_001658.2  ADP-ribosylation factor-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001658.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI631767, BC002530, BG706294
      Consensus CDS
      CCDS8088.1
      UniProtKB/Swiss-Prot
      G3V184, P36404, Q9BUK8
      UniProtKB/TrEMBL
      Q53YD8
      Related
      ENSP00000246747.4, ENST00000246747.9
      Conserved Domains (1) summary
      cd04154
      Location:3175
      Arl2; Arf-like 2 (Arl2) GTPase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65014160..65022184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65007423..65015448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)