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    ACP3 acid phosphatase 3 [ Homo sapiens (human) ]

    Gene ID: 55, updated on 9-Dec-2024

    Summary

    Official Symbol
    ACP3provided by HGNC
    Official Full Name
    acid phosphatase 3provided by HGNC
    Primary source
    HGNC:HGNC:125
    See related
    Ensembl:ENSG00000014257 MIM:171790; AllianceGenome:HGNC:125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACPP; 5'-NT; ACP-3; TM-PAP
    Summary
    This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
    Expression
    Restricted expression toward prostate (RPKM 1149.8) See more
    Orthologs
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    Genomic context

    See ACP3 in Genome Data Viewer
    Location:
    3q22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (132317407..132368302)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (135061847..135112776)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (132036251..132087146)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 16 Neighboring gene uncharacterized LOC124906374 Neighboring gene uncharacterized LOC124909435 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:132099837-132100615 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:132100616-132101393 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:132101394-132102172 Neighboring gene G2E3 pseudogene 1 Neighboring gene NIP7 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables XMP 5'-nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acid phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables choline binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lysophosphatidic acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiamine phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in adenosine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of adenosine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of adenosine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in thiamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane HDA PubMed 
    located_in multivesicular body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    prostatic acid phosphatase
    Names
    TMPase
    acid phosphatase, prostate
    ecto-5'-nucleotidase
    prostatic acid phosphotase
    protein tyrosine phosphatase ACP3
    thiamine monophosphatase
    NP_001090.2
    NP_001127666.1
    NP_001278966.1
    XP_011511248.1
    XP_011511249.1
    XP_054203008.1
    XP_054203009.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047032.1 RefSeqGene

      Range
      5041..46475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001099.5NP_001090.2  prostatic acid phosphatase isoform PAP precursor

      See identical proteins and their annotated locations for NP_001090.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter, secreted isoform (PAP).
      Source sequence(s)
      AA578274, AC020633, BC008493, BC016344
      Consensus CDS
      CCDS3073.1
      UniProtKB/Swiss-Prot
      D3DNC6, P15309, Q5FBY0, Q96KY0, Q96QK9, Q96QM0
      Related
      ENSP00000337471.5, ENST00000336375.10
      Conserved Domains (1) summary
      cd07061
      Location:34332
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    2. NM_001134194.2NP_001127666.1  prostatic acid phosphatase isoform TM-PAP precursor

      See identical proteins and their annotated locations for NP_001127666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 3' end compared to variant 1 and encodes a longer isoform (TM-PAP) with a distinct C-terminus compared to isoform PAP. TM-PAP is a type 1 transmembrane protein.
      Source sequence(s)
      AW136372, BC007460, BC008493, BQ100881, DC383453
      Consensus CDS
      CCDS46916.1
      UniProtKB/Swiss-Prot
      P15309
      Related
      ENSP00000323036.8, ENST00000351273.12
      Conserved Domains (1) summary
      cd07061
      Location:34332
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    3. NM_001292037.2NP_001278966.1  prostatic acid phosphatase isoform 3 precursor

      See identical proteins and their annotated locations for NP_001278966.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform PAP.
      Source sequence(s)
      AC020633, AK300540, DC383453
      Consensus CDS
      CCDS77818.1
      UniProtKB/Swiss-Prot
      P15309
      Related
      ENSP00000417744.1, ENST00000475741.5
      Conserved Domains (1) summary
      cd07061
      Location:34299
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      132317407..132368302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512947.3XP_011511249.1  prostatic acid phosphatase isoform X2

      Conserved Domains (1) summary
      cd07061
      Location:34299
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    2. XM_011512946.2XP_011511248.1  prostatic acid phosphatase isoform X1

      Conserved Domains (1) summary
      cd07061
      Location:34332
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      135061847..135112776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347034.1XP_054203009.1  prostatic acid phosphatase isoform X2

    2. XM_054347033.1XP_054203008.1  prostatic acid phosphatase isoform X1