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    PLA2G4C phospholipase A2 group IVC [ Homo sapiens (human) ]

    Gene ID: 8605, updated on 9-Dec-2024

    Summary

    Official Symbol
    PLA2G4Cprovided by HGNC
    Official Full Name
    phospholipase A2 group IVCprovided by HGNC
    Primary source
    HGNC:HGNC:9037
    See related
    Ensembl:ENSG00000105499 MIM:603602; AllianceGenome:HGNC:9037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPLA2-gamma
    Summary
    This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
    Expression
    Ubiquitous expression in brain (RPKM 6.1), heart (RPKM 5.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PLA2G4C in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48047846..48110817, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51041707..51105372, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48551103..48614074, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene epididymal sperm binding protein 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:48522004-48523203 Neighboring gene calcium binding protein 5 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48564610-48565203 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48565204-48565796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48565797-48566389 Neighboring gene PLA2G4C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10871 Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48673083-48673742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14872 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48691653-48691885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48699771-48700283

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
    env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    Tat tat HIV-1 Tat upregulates phospholipase A2, group IVC (PLA2G4C) expression in Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ42247, FLJ44164, DKFZp586C0423

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-independent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysophospholipase activity TAS
    Traceable Author Statement
    more info
     
    enables phospholipase A1 activity TAS
    Traceable Author Statement
    more info
     
    enables phospholipid binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytosolic phospholipase A2 gamma
    Names
    cytosolic lysophospholipase
    cytosolic lysophospholipid O-acyltransferase
    phospholipase A2, group IVC (cytosolic, calcium-independent)
    NP_001152794.1
    NP_001152795.1
    NP_003697.2
    XP_011525733.1
    XP_011525734.1
    XP_016882903.1
    XP_047295540.1
    XP_047295541.1
    XP_054178438.1
    XP_054178439.1
    XP_054178440.1
    XP_054178441.1
    XP_054178442.1
    XP_054178443.1
    XP_054178444.1
    XP_054178445.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016021.1 RefSeqGene

      Range
      5036..68007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001159322.2NP_001152794.1  cytosolic phospholipase A2 gamma isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC010458, AC011466, AK295400
      Consensus CDS
      CCDS59403.1
      UniProtKB/Swiss-Prot
      Q9UP65
      Related
      ENSP00000472546.1, ENST00000599111.5
      Conserved Domains (1) summary
      cd07202
      Location:19539
      cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
    2. NM_001159323.2NP_001152795.1  cytosolic phospholipase A2 gamma isoform 3

      See identical proteins and their annotated locations for NP_001152795.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC010458, AC011466, AK022440
      Consensus CDS
      CCDS54286.1
      UniProtKB/Swiss-Prot
      Q9UP65
      Related
      ENSP00000346228.2, ENST00000354276.7
      Conserved Domains (1) summary
      cd07202
      Location:4527
      cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
    3. NM_003706.3NP_003697.2  cytosolic phospholipase A2 gamma isoform 1 precursor

      See identical proteins and their annotated locations for NP_003697.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AC010458, AC011466, BC063416
      Consensus CDS
      CCDS12710.1
      UniProtKB/Swiss-Prot
      B2RB71, B4DI40, O75457, Q6IBI8, Q9UG68, Q9UP65
      Related
      ENSP00000469473.1, ENST00000599921.6
      Conserved Domains (1) summary
      cd07202
      Location:4529
      cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      48047846..48110817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527431.4XP_011525733.1  cytosolic phospholipase A2 gamma isoform X1

      Conserved Domains (1) summary
      cd07202
      Location:4511
      cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
    2. XM_047439585.1XP_047295541.1  cytosolic phospholipase A2 gamma isoform X4

    3. XM_047439584.1XP_047295540.1  cytosolic phospholipase A2 gamma isoform X3

    4. XM_011527432.4XP_011525734.1  cytosolic phospholipase A2 gamma isoform X2

      Conserved Domains (1) summary
      cl11396
      Location:4425
      Patatin_and_cPLA2; Patatins and Phospholipases
    5. XM_017027414.3XP_016882903.1  cytosolic phospholipase A2 gamma isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      51041707..51105372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322464.1XP_054178439.1  cytosolic phospholipase A2 gamma isoform X1

    2. XM_054322463.1XP_054178438.1  cytosolic phospholipase A2 gamma isoform X6

    3. XM_054322470.1XP_054178445.1  cytosolic phospholipase A2 gamma isoform X8

    4. XM_054322468.1XP_054178443.1  cytosolic phospholipase A2 gamma isoform X4

    5. XM_054322467.1XP_054178442.1  cytosolic phospholipase A2 gamma isoform X3

    6. XM_054322466.1XP_054178441.1  cytosolic phospholipase A2 gamma isoform X7

    7. XM_054322465.1XP_054178440.1  cytosolic phospholipase A2 gamma isoform X2

    8. XM_054322469.1XP_054178444.1  cytosolic phospholipase A2 gamma isoform X5