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    GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [ Homo sapiens (human) ]

    Gene ID: 26330, updated on 9-Dec-2024

    Summary

    Official Symbol
    GAPDHSprovided by HGNC
    Official Full Name
    glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by HGNC
    Primary source
    HGNC:HGNC:24864
    See related
    Ensembl:ENSG00000105679 MIM:609169; AllianceGenome:HGNC:24864
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278
    Summary
    This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 87.7) and thyroid (RPKM 2.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GAPDHS in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35533456..35545319)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38078404..38090265)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36024358..36036221)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35991019-35991520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35991521-35992020 Neighboring gene dermokine Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36016123-36016795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36017917-36018418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36019864-36020364 Neighboring gene suprabasin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14483 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36031035-36031534 Neighboring gene TMEM147 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36033929-36034430 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36036145-36036837 Neighboring gene transmembrane protein 147 Neighboring gene ATPase H+/K+ transporting subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36048997-36049612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14485

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glycolytic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    glyceraldehyde-3-phosphate dehydrogenase, testis-specific
    Names
    epididymis secretory protein Li 278
    spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2
    spermatogenic glyceraldehyde-3-phosphate dehydrogenase
    NP_055179.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046898.1 RefSeqGene

      Range
      5045..16908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014364.5NP_055179.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific

      See identical proteins and their annotated locations for NP_055179.1

      Status: REVIEWED

      Source sequence(s)
      AC002389, BC036373, BP370184
      Consensus CDS
      CCDS12465.1
      UniProtKB/Swiss-Prot
      B2RC82, O14556, O60823, Q6JTT9, Q9HCU6
      UniProtKB/TrEMBL
      A0A0K0K1K1
      Related
      ENSP00000222286.3, ENST00000222286.9
      Conserved Domains (3) summary
      COG0057
      Location:78408
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam00044
      Location:78224
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      pfam02800
      Location:229386
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35533456..35545319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38078404..38090265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)