U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HTR7 5-hydroxytryptamine receptor 7 [ Homo sapiens (human) ]

    Gene ID: 3363, updated on 9-Dec-2024

    Summary

    Official Symbol
    HTR7provided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 7provided by HGNC
    Primary source
    HGNC:HGNC:5302
    See related
    Ensembl:ENSG00000148680 MIM:182137; AllianceGenome:HGNC:5302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-HT7
    Summary
    The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 6.1), urinary bladder (RPKM 2.0) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HTR7 in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (90740823..90858039, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (91624488..91741713, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (92500580..92617796, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2653 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:92243978-92245177 Neighboring gene uncharacterized LOC124902478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3755 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:92564844-92565562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2601 Neighboring gene Sharpr-MPRA regulatory region 7939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3757 Neighboring gene ribonuclease P/MRP subunit p30 Neighboring gene ankyrin repeat domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common genetic variants and gene expression associated with white matter microstructure in the human brain.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 7
    Names
    5-HT-7
    5-HT-X
    5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029218.1 RefSeqGene

      Range
      4876..122092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000872.5NP_000863.1  5-hydroxytryptamine receptor 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) results from the alternative usage of the first of two tandemly arranged splice donor sites at the 5' end of intron 2, which causes the protein to have a 13 amino acid longer carboxy tail relative to isoform b.
      Source sequence(s)
      AL360011, BC047526, BG108256
      Consensus CDS
      CCDS7409.1
      UniProtKB/Swiss-Prot
      P34969
      Related
      ENSP00000277874.6, ENST00000277874.10
      Conserved Domains (1) summary
      cd15329
      Location:97395
      7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_019859.4NP_062873.1  5-hydroxytryptamine receptor 7 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) results from the inclusion of a 98 base pair exon cassette (exon D) at the exon II/exon III boundary, as compared to splice variant a. The inclusion of exon D results in a protein with a carboxy terminal end 34 amino acids longer than the splice variant a protein.
      Source sequence(s)
      AL360011, BC047526, BG108256, U68488
      Consensus CDS
      CCDS7408.1
      UniProtKB/Swiss-Prot
      B5BUP6, P34969, P78336, P78372, P78516, Q5VX01, Q5VX02, Q5VX03
      Related
      ENSP00000337949.3, ENST00000336152.8
      Conserved Domains (2) summary
      pfam00001
      Location:98384
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98215
      7tm_4; Olfactory receptor
    3. NM_019860.4NP_062874.1  5-hydroxytryptamine receptor 7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) results from the alternative usage of the second of the two tandemly arranged splice donor sites at the 5' end of intron 2, which causes an in-frame stop codon and shortens the protein's carboxy tail by 13 amino acids relative to isoform a.
      Source sequence(s)
      AL360011, BC047526, BG108256, U68487
      Consensus CDS
      CCDS7410.1
      UniProtKB/Swiss-Prot
      P34969
      Related
      ENSP00000360784.2, ENST00000371719.2
      Conserved Domains (1) summary
      cd15329
      Location:97395
      7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      90740823..90858039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447973.2XP_024303741.1  5-hydroxytryptamine receptor 7 isoform X1

      Conserved Domains (2) summary
      cd15329
      Location:319
      7tmA_5-HT7; TM helix 4 [structural motif]
      cl28897
      Location:1197
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      91624488..91741713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365712.1XP_054221687.1  5-hydroxytryptamine receptor 7 isoform X1