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    NPAS1 neuronal PAS domain protein 1 [ Homo sapiens (human) ]

    Gene ID: 4861, updated on 3-Dec-2024

    Summary

    Official Symbol
    NPAS1provided by HGNC
    Official Full Name
    neuronal PAS domain protein 1provided by HGNC
    Primary source
    HGNC:HGNC:7894
    See related
    Ensembl:ENSG00000130751 MIM:603346; AllianceGenome:HGNC:7894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOP5; PASD5; bHLHe11
    Summary
    The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 1.1), stomach (RPKM 0.8) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NPAS1 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47019837..47045775)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49845776..49871084)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47523094..47549033)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47341466-47341966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47358600-47359538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47359539-47360475 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10833 Neighboring gene adaptor related protein complex 2 subunit sigma 1 Neighboring gene Rho GTPase activating protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10834 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:47466169-47467368 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47479369-47480226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47480227-47481082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47505718-47506463 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47506464-47507210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47508684-47509262 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47514658-47514871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10835 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47533967-47534068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47534993-47535494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10836 Neighboring gene Sharpr-MPRA regulatory region 8906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47552307-47552824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47552825-47553342 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47557751-47558307 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47562983-47563503 Neighboring gene MPRA-validated peak3531 silencer Neighboring gene transmembrane protein 160 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47613025-47613752 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47615210-47615938 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47615939-47616666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14858

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in startle response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuronal PAS domain-containing protein 1
    Names
    PAS domain-containing protein 5
    basic-helix-loop-helix-PAS protein MOP5
    class E basic helix-loop-helix protein 11
    member of PAS protein 5
    member of PAS superfamily 5
    neuronal PAS1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321086.2NP_001308015.1  neuronal PAS domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC008755, AK299128, BC039016
      Consensus CDS
      CCDS82371.1
      UniProtKB/TrEMBL
      M0R1R8
      Related
      ENSP00000398689.2, ENST00000439365.6
      Conserved Domains (1) summary
      smart00091
      Location:119178
      PAS; PAS domain
    2. NM_002517.4NP_002508.2  neuronal PAS domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_002508.2

      Status: REVIEWED

      Source sequence(s)
      AC008755, BC039016, CA420408
      Consensus CDS
      CCDS12694.1
      UniProtKB/Swiss-Prot
      B4DR69, Q99632, Q99742, Q9BY83
      Related
      ENSP00000469142.1, ENST00000602212.6
      Conserved Domains (3) summary
      smart00091
      Location:141198
      PAS; PAS domain
      cd00083
      Location:4596
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam08447
      Location:315386
      PAS_3; PAS fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      47019837..47045775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438882.1XP_047294838.1  neuronal PAS domain-containing protein 1 isoform X2

    2. XM_047438885.1XP_047294841.1  neuronal PAS domain-containing protein 1 isoform X7

    3. XM_047438881.1XP_047294837.1  neuronal PAS domain-containing protein 1 isoform X1

    4. XM_047438886.1XP_047294842.1  neuronal PAS domain-containing protein 1 isoform X8

    5. XM_024451526.2XP_024307294.2  neuronal PAS domain-containing protein 1 isoform X5

    6. XM_047438883.1XP_047294839.1  neuronal PAS domain-containing protein 1 isoform X3

    7. XM_017026844.2XP_016882333.1  neuronal PAS domain-containing protein 1 isoform X4

    8. XM_047438884.1XP_047294840.1  neuronal PAS domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      M0R2M8
    9. XM_047438887.1XP_047294843.1  neuronal PAS domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      M0R2M8
      Related
      ENSP00000472679.1, ENST00000602189.5
    10. XM_047438889.1XP_047294845.1  neuronal PAS domain-containing protein 1 isoform X11

    11. XM_047438888.1XP_047294844.1  neuronal PAS domain-containing protein 1 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      49845776..49871084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321110.1XP_054177085.1  neuronal PAS domain-containing protein 1 isoform X2

    2. XM_054321115.1XP_054177090.1  neuronal PAS domain-containing protein 1 isoform X7

    3. XM_054321109.1XP_054177084.1  neuronal PAS domain-containing protein 1 isoform X1

    4. XM_054321111.1XP_054177086.1  neuronal PAS domain-containing protein 1 isoform X3

    5. XM_054321116.1XP_054177091.1  neuronal PAS domain-containing protein 1 isoform X8

    6. XM_054321113.1XP_054177088.1  neuronal PAS domain-containing protein 1 isoform X5

    7. XM_054321112.1XP_054177087.1  neuronal PAS domain-containing protein 1 isoform X4

    8. XM_054321114.1XP_054177089.1  neuronal PAS domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      M0R2M8
    9. XM_054321118.1XP_054177093.1  neuronal PAS domain-containing protein 1 isoform X10

    10. XM_054321117.1XP_054177092.1  neuronal PAS domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      M0R2M8
    11. XM_054321119.1XP_054177094.1  neuronal PAS domain-containing protein 1 isoform X11