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    RO60 Ro60, Y RNA binding protein [ Homo sapiens (human) ]

    Gene ID: 6738, updated on 9-Dec-2024

    Summary

    Official Symbol
    RO60provided by HGNC
    Official Full Name
    Ro60, Y RNA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:11313
    See related
    Ensembl:ENSG00000116747 MIM:600063; AllianceGenome:HGNC:11313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSA2; RORNP; TROVE2
    Summary
    Enables RNA binding activity. Involved in cellular response to interferon-alpha and regulation of gene expression. Located in cytosol and nuclear body. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RO60 in Genome Data Viewer
    Location:
    1q31.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (193059612..193091777)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (192406634..192438985)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (193028742..193060907)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 101 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:192979786-192979951 Neighboring gene ubiquitin C-terminal hydrolase L5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2265 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193028176-193028908 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193028909-193029641 Neighboring gene small Cajal body-specific RNA 18B Neighboring gene Sharpr-MPRA regulatory region 7925 Neighboring gene glutaredoxin 2 Neighboring gene uncharacterized LOC124904474 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193082253-193083159 Neighboring gene Sharpr-MPRA regulatory region 4625

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables U2 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase III TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA-binding protein RO60
    Names
    60 kDa ribonucleoprotein Ro
    Ro/SSA 60kDa
    Sjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro)
    TROVE domain family member 2
    gastric cancer multi-drug resistance protein
    ro60 autoantigen
    sjoegren syndrome type A antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042369.2NP_001035828.1  RNA-binding protein RO60 isoform 1

      See identical proteins and their annotated locations for NP_001035828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AI433657, CX761715, M25077
      Consensus CDS
      CCDS41449.1
      UniProtKB/Swiss-Prot
      P10155
      Related
      ENSP00000356414.3, ENST00000367444.7
      Conserved Domains (2) summary
      pfam05731
      Location:17369
      TROVE; TROVE domain
      cl00057
      Location:370505
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. NM_001042370.2NP_001035829.2  RNA-binding protein RO60 isoform 3

      See identical proteins and their annotated locations for NP_001035829.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI433657, AL136370, AY205315, CX761715
      Consensus CDS
      CCDS41450.2
      UniProtKB/Swiss-Prot
      P10155
      Related
      ENSP00000356415.3, ENST00000367445.7
      Conserved Domains (2) summary
      pfam05731
      Location:17369
      TROVE; TROVE domain
      cl00057
      Location:372489
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    3. NM_001173524.2NP_001166995.1  RNA-binding protein RO60 isoform 2

      See identical proteins and their annotated locations for NP_001166995.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, the 3' coding region and the 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AK314594, AL136370, BC036658, M25077
      Consensus CDS
      CCDS1379.1
      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
      Related
      ENSP00000383752.2, ENST00000400968.7
      Conserved Domains (2) summary
      pfam05731
      Location:17369
      TROVE; TROVE domain
      cl00057
      Location:372489
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    4. NM_001173525.1NP_001166996.1  RNA-binding protein RO60 isoform 4

      See identical proteins and their annotated locations for NP_001166996.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI433657, AL136370, AY205314, CX761715
      Consensus CDS
      CCDS53451.1
      UniProtKB/Swiss-Prot
      P10155
      Related
      ENSP00000356413.1, ENST00000367443.5
      Conserved Domains (2) summary
      pfam05731
      Location:17369
      TROVE; TROVE domain
      cl00057
      Location:370505
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    5. NM_001331020.2NP_001317949.1  RNA-binding protein RO60 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL136370
      Consensus CDS
      CCDS86042.1
      UniProtKB/TrEMBL
      A0A024R941, A0A9K3Y7X9, G5E9R9
      Related
      ENSP00000472298.1, ENST00000432079.5
      Conserved Domains (2) summary
      cd00198
      Location:97214
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam05731
      Location:194
      TROVE; TROVE domain
    6. NM_004600.5NP_004591.2  RNA-binding protein RO60 isoform 2

      See identical proteins and their annotated locations for NP_004591.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AL136370, BC036658, CX761715
      Consensus CDS
      CCDS1379.1
      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
      Related
      ENSP00000356416.3, ENST00000367446.7
      Conserved Domains (2) summary
      pfam05731
      Location:17369
      TROVE; TROVE domain
      cl00057
      Location:372489
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      193059612..193091777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428924.1XP_047284880.1  RNA-binding protein RO60 isoform X2

      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
    2. XM_006711496.4XP_006711559.1  RNA-binding protein RO60 isoform X1

      See identical proteins and their annotated locations for XP_006711559.1

      Conserved Domains (2) summary
      pfam05731
      Location:17391
      TROVE; TROVE domain
      cl00057
      Location:392527
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    3. XM_006711497.4XP_006711560.1  RNA-binding protein RO60 isoform X2

      See identical proteins and their annotated locations for XP_006711560.1

      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
      Conserved Domains (2) summary
      pfam05731
      Location:17369
      TROVE; TROVE domain
      cl00057
      Location:372489
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    4. XM_011509922.3XP_011508224.1  RNA-binding protein RO60 isoform X3

      See identical proteins and their annotated locations for XP_011508224.1

      UniProtKB/TrEMBL
      A0A024R941, A0A9K3Y7X9, G5E9R9
      Conserved Domains (2) summary
      cd00198
      Location:97214
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam05731
      Location:194
      TROVE; TROVE domain
    5. XM_006711495.5XP_006711558.1  RNA-binding protein RO60 isoform X1

      See identical proteins and their annotated locations for XP_006711558.1

      Conserved Domains (2) summary
      pfam05731
      Location:17391
      TROVE; TROVE domain
      cl00057
      Location:392527
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    6. XM_017002183.2XP_016857672.1  RNA-binding protein RO60 isoform X3

      UniProtKB/TrEMBL
      A0A024R941, A0A9K3Y7X9, G5E9R9
      Conserved Domains (2) summary
      cd00198
      Location:97214
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam05731
      Location:194
      TROVE; TROVE domain
    7. XM_047428920.1XP_047284876.1  RNA-binding protein RO60 isoform X1

    8. XM_017002181.3XP_016857670.1  RNA-binding protein RO60 isoform X2

      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
      Conserved Domains (2) summary
      pfam05731
      Location:17369
      TROVE; TROVE domain
      cl00057
      Location:372489
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    9. XM_017002180.2XP_016857669.1  RNA-binding protein RO60 isoform X1

      Conserved Domains (2) summary
      pfam05731
      Location:17391
      TROVE; TROVE domain
      cl00057
      Location:392527
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    10. XM_017002182.2XP_016857671.1  RNA-binding protein RO60 isoform X2

      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
      Conserved Domains (2) summary
      pfam05731
      Location:17369
      TROVE; TROVE domain
      cl00057
      Location:372489
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      192406634..192438985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338473.1XP_054194448.1  RNA-binding protein RO60 isoform X2

      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
    2. XM_054338474.1XP_054194449.1  RNA-binding protein RO60 isoform X2

      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
    3. XM_054338470.1XP_054194445.1  RNA-binding protein RO60 isoform X1

    4. XM_054338472.1XP_054194447.1  RNA-binding protein RO60 isoform X2

      UniProtKB/Swiss-Prot
      B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
    5. XM_054338475.1XP_054194450.1  RNA-binding protein RO60 isoform X3

      UniProtKB/TrEMBL
      A0A024R941, A0A9K3Y7X9, G5E9R9
    6. XM_054338469.1XP_054194444.1  RNA-binding protein RO60 isoform X1

    7. XM_054338476.1XP_054194451.1  RNA-binding protein RO60 isoform X3

      UniProtKB/TrEMBL
      A0A024R941, A0A9K3Y7X9, G5E9R9
    8. XM_054338471.1XP_054194446.1  RNA-binding protein RO60 isoform X1