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    Cpvl carboxypeptidase, vitellogenic-like [ Mus musculus (house mouse) ]

    Gene ID: 71287, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cpvlprovided by MGI
    Official Full Name
    carboxypeptidase, vitellogenic-likeprovided by MGI
    Primary source
    MGI:MGI:1918537
    See related
    Ensembl:ENSMUSG00000052955 AllianceGenome:MGI:1918537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HVLP; 4933436L16Rik
    Summary
    This gene encodes a member of the serine carboxypeptidase family of proteases that cleave amino acids from the C-terminus of a protein substrate. The human ortholog of this gene, where it was first characterized, was found to be upregulated during the maturation of monocytes to macrophages. The encoded protein may be involved in antigen processing, digestion of phagocytosed proteins in the lysosome and lamellipodium formation. Disruption of this gene in mice was found to cause embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
    Expression
    Restricted expression toward testis adult (RPKM 4.9) See more
    Orthologs
    human all
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    Genomic context

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    See Cpvl in Genome Data Viewer
    Location:
    6 B3; 6 26.19 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (53850106..53955658, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (53873121..53978673, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15935 Neighboring gene predicted gene 16499 Neighboring gene STARR-seq mESC enhancer starr_15936 Neighboring gene STARR-seq mESC enhancer starr_15937 Neighboring gene predicted gene, 22910 Neighboring gene predicted gene, 33716 Neighboring gene RIKEN cDNA 4921529L05 gene Neighboring gene STARR-seq mESC enhancer starr_15940 Neighboring gene STARR-seq mESC enhancer starr_15942 Neighboring gene chimerin 2 Neighboring gene RIKEN cDNA 9530036M11 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Carboxypeptidase Vitellogenic-Like Promotes the Proliferation and Metastasis of Osteosarcoma through the TGF-β/Smad Signaling Pathway. Wang L, et al. Ann Clin Lab Sci, 2023 Nov. PMID 38182149
    2. Tagged mutagenesis by efficient Minos-based germ line transposition. de Wit T, et al. Mol Cell Biol, 2010 Jan. PMID 19884347, Free PMC Article
    3. Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice. Srivastava U, et al. Arterioscler Thromb Vasc Biol, 2012 Oct. PMID 22837474, Free PMC Article
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Carboxypeptidase Vitellogenic-Like Promotes the Proliferation and Metastasis of Osteosarcoma through the TGF-beta/Smad Signaling Pathway.
      Title: Carboxypeptidase Vitellogenic-Like Promotes the Proliferation and Metastasis of Osteosarcoma through the TGF-β/Smad Signaling Pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 
    • Transposon induced (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable serine carboxypeptidase CPVL
    NP_001276642.1
    NP_001276643.1
    NP_082025.1
    XP_006506676.1
    XP_006506678.1
    XP_006506680.1
    XP_006506682.1
    XP_006506683.1
    XP_006506684.1
    XP_006506685.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289713.1 → NP_001276642.1  probable serine carboxypeptidase CPVL isoform 1 precursor

      See identical proteins and their annotated locations for NP_001276642.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK017087, BC137839
      Consensus CDS
      CCDS51777.1
      UniProtKB/Swiss-Prot
      B2RQB1, Q9D3S9
      UniProtKB/TrEMBL
      B7ZN25
      Related
      ENSMUSP00000144942.2, ENSMUST00000204674.3
      Conserved Domains (1) summary
      pfam00450
      Location:72 → 468
      Peptidase_S10; Serine carboxypeptidase

    2. NM_001289714.1 → NP_001276643.1  probable serine carboxypeptidase CPVL isoform 2 precursor

      See identical proteins and their annotated locations for NP_001276643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK017087
      Consensus CDS
      CCDS85050.1
      UniProtKB/TrEMBL
      B7ZN25
      Related
      ENSMUSP00000145288.2, ENSMUST00000203101.3
      Conserved Domains (1) summary
      cl08270
      Location:72 → 424
      Peptidase_S10; Serine carboxypeptidase

    3. NM_027749.2 → NP_082025.1  probable serine carboxypeptidase CPVL isoform 1 precursor

      See identical proteins and their annotated locations for NP_082025.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK017087, BC137839
      Consensus CDS
      CCDS51777.1
      UniProtKB/Swiss-Prot
      B2RQB1, Q9D3S9
      UniProtKB/TrEMBL
      B7ZN25
      Related
      ENSMUSP00000131462.2, ENSMUST00000166545.2
      Conserved Domains (1) summary
      pfam00450
      Location:72 → 468
      Peptidase_S10; Serine carboxypeptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      53850106..53955658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506615.4 → XP_006506678.1  probable serine carboxypeptidase CPVL isoform X2

      See identical proteins and their annotated locations for XP_006506678.1

      UniProtKB/Swiss-Prot
      B2RQB1, Q9D3S9
      UniProtKB/TrEMBL
      B7ZN25
      Conserved Domains (1) summary
      pfam00450
      Location:72 → 468
      Peptidase_S10; Serine carboxypeptidase

    2. XM_006506619.3 → XP_006506682.1  probable serine carboxypeptidase CPVL isoform X4

      UniProtKB/TrEMBL
      B7ZN25
      Conserved Domains (1) summary
      cl08270
      Location:78 → 389
      Peptidase_S10; Serine carboxypeptidase

    3. XM_006506617.2 → XP_006506680.1  probable serine carboxypeptidase CPVL isoform X3

      UniProtKB/TrEMBL
      B7ZN25
      Conserved Domains (1) summary
      cl08270
      Location:78 → 430
      Peptidase_S10; Serine carboxypeptidase

    4. XM_006506613.2 → XP_006506676.1  probable serine carboxypeptidase CPVL isoform X1

      UniProtKB/TrEMBL
      B7ZN25
      Conserved Domains (1) summary
      pfam00450
      Location:78 → 474
      Peptidase_S10; Serine carboxypeptidase

    5. XM_006506622.4 → XP_006506685.1  probable serine carboxypeptidase CPVL isoform X5

      See identical proteins and their annotated locations for XP_006506685.1

      Conserved Domains (1) summary
      cl08270
      Location:1 → 319
      Peptidase_S10; Serine carboxypeptidase

    6. XM_006506620.4 → XP_006506683.1  probable serine carboxypeptidase CPVL isoform X5

      See identical proteins and their annotated locations for XP_006506683.1

      Conserved Domains (1) summary
      cl08270
      Location:1 → 319
      Peptidase_S10; Serine carboxypeptidase

    7. XM_006506621.2 → XP_006506684.1  probable serine carboxypeptidase CPVL isoform X5

      See identical proteins and their annotated locations for XP_006506684.1

      Conserved Domains (1) summary
      cl08270
      Location:1 → 319
      Peptidase_S10; Serine carboxypeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3S9.2 GenPept UniProtKB/Swiss-Prot:Q9D3S9

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