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    RAD54L2 RAD54 like 2 [ Homo sapiens (human) ]

    Gene ID: 23132, updated on 9-Dec-2024

    Summary

    Official Symbol
    RAD54L2provided by HGNC
    Official Full Name
    RAD54 like 2provided by HGNC
    Primary source
    HGNC:HGNC:29123
    See related
    Ensembl:ENSG00000164080 MIM:620006; AllianceGenome:HGNC:29123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARIP4; HSPC325; SRISNF2L
    Summary
    Predicted to enable protein kinase binding activity and transcription coregulator activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 3.3), spleen (RPKM 2.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RAD54L2 in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51538719..51668660)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51569157..51700178)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51572735..51702676)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 15B Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14414 Neighboring gene uncharacterized LOC105377085 Neighboring gene Sharpr-MPRA regulatory region 10823 Neighboring gene Sharpr-MPRA regulatory region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19920 Neighboring gene NANOG hESC enhancer GRCh37_chr3:51578193-51578834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51581873-51582372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51589128-51590066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51617110-51617895 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:51627487-51627690 Neighboring gene RNA, U6atac small nuclear 29, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51696703-51697203 Neighboring gene uncharacterized LOC124906237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51712641-51713399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51721007-51721622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51724855-51725678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51725679-51726501 Neighboring gene testis expressed 264, ER-phagy receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51737956-51738824 Neighboring gene RNA, 5S ribosomal pseudogene 132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51750466-51751323 Neighboring gene glutamate metabotropic receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21396, FLJ22400, KIAA0809

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    helicase ARIP4
    Names
    AR interacting protein 4
    RAD54-like protein 2
    androgen receptor-interacting protein 4
    NP_001309182.1
    NP_001309185.1
    NP_001374795.1
    NP_001374796.1
    NP_001374798.1
    NP_055921.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322253.2NP_001309182.1  helicase ARIP4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC099050, AC113933
      Consensus CDS
      CCDS33765.2
      UniProtKB/Swiss-Prot
      Q8TB57, Q9BV54, Q9Y4B4
      UniProtKB/TrEMBL
      H0Y760
      Conserved Domains (3) summary
      PHA03247
      Location:11061414
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:134907
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:271547
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
    2. NM_001322256.2NP_001309185.1  helicase ARIP4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC099050, AC113933
      Consensus CDS
      CCDS33765.2
      UniProtKB/Swiss-Prot
      Q8TB57, Q9BV54, Q9Y4B4
      UniProtKB/TrEMBL
      H0Y760
      Conserved Domains (3) summary
      PHA03247
      Location:11061414
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:134907
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:271547
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
    3. NM_001387866.1NP_001374795.1  helicase ARIP4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC099050, AC113933
      UniProtKB/TrEMBL
      H0Y760
      Conserved Domains (3) summary
      PHA03247
      Location:11041412
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:134905
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:271547
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
    4. NM_001387867.1NP_001374796.1  helicase ARIP4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC099050, AC113933
      UniProtKB/TrEMBL
      H0Y760
      Conserved Domains (3) summary
      PHA03247
      Location:11011409
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:134902
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:271542
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
    5. NM_001387869.1NP_001374798.1  helicase ARIP4 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC099050, AC113933
      UniProtKB/TrEMBL
      H0Y760
      Related
      ENSP00000410283.1, ENST00000432863.1
      Conserved Domains (3) summary
      PHA03247
      Location:10541362
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:82855
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:219495
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
    6. NM_015106.4NP_055921.2  helicase ARIP4 isoform a

      See identical proteins and their annotated locations for NP_055921.2

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC099050, AC113933
      Consensus CDS
      CCDS33765.2
      UniProtKB/Swiss-Prot
      Q8TB57, Q9BV54, Q9Y4B4
      UniProtKB/TrEMBL
      H0Y760
      Related
      ENSP00000507587.1, ENST00000684192.1
      Conserved Domains (3) summary
      PHA03247
      Location:11061414
      PHA03247; large tegument protein UL36; Provisional
      COG0553
      Location:134907
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:271547
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      51538719..51668660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      51569157..51700178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001322257.1: Suppressed sequence

      Description
      NM_001322257.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.