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    DPT dermatopontin [ Homo sapiens (human) ]

    Gene ID: 1805, updated on 9-Dec-2024

    Summary

    Official Symbol
    DPTprovided by HGNC
    Official Full Name
    dermatopontinprovided by HGNC
    Primary source
    HGNC:HGNC:3011
    See related
    Ensembl:ENSG00000143196 MIM:125597; AllianceGenome:HGNC:3011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRAMP
    Summary
    Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 269.7), heart (RPKM 73.0) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DPT in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (168695468..168729206, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (168050592..168084377, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168664706..168698444, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 21 Neighboring gene X-C motif chemokine ligand 1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:168594433-168594934 Neighboring gene uncharacterized LOC105371604 Neighboring gene uncharacterized LOC124904452 Neighboring gene long intergenic non-protein coding RNA 626

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    EBI GWAS Catalog
    Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef-induced upregulation of tyrosine-rich acidic matrix protein (TRAMP) is found in Nef expressing HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    dermatopontin
    Names
    tyrosine-rich acidic matrix protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001937.5NP_001928.2  dermatopontin precursor

      See identical proteins and their annotated locations for NP_001928.2

      Status: VALIDATED

      Source sequence(s)
      AL049798, BC033736, BP257325
      Consensus CDS
      CCDS1275.1
      UniProtKB/Swiss-Prot
      A8K981, Q07507, Q8N4R2, Q9UIX8
      Related
      ENSP00000356791.3, ENST00000367817.4
      Conserved Domains (1) summary
      pfam14704
      Location:43192
      DERM; Dermatopontin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      168695468..168729206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      168050592..168084377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)