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    PPP1R3C protein phosphatase 1 regulatory subunit 3C [ Homo sapiens (human) ]

    Gene ID: 5507, updated on 9-Dec-2024

    Summary

    Official Symbol
    PPP1R3Cprovided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:9293
    See related
    Ensembl:ENSG00000119938 MIM:602999; AllianceGenome:HGNC:9293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTG; PPP1R5
    Summary
    This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in heart (RPKM 69.5), esophagus (RPKM 32.0) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PPP1R3C in Genome Data Viewer
    Location:
    10q23.32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (91628442..91633071, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (92511668..92516296, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93388199..93392828, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene HECTD2 antisense RNA 1 Neighboring gene uncharacterized LOC105378433 Neighboring gene ribosomal protein S27 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 13147 Neighboring gene VISTA enhancer hs1950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:93392459-93392960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:93392961-93393460 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:93412611-93413810 Neighboring gene uncharacterized LOC107984253 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 28 Neighboring gene Sharpr-MPRA regulatory region 15620

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycogen metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 3C
    Names
    PP1 subunit R5
    Phosphatase 1, regulatory inhibitor subunit 5
    protein phosphatase 1 regulatory subunit 5
    protein phosphatase 1, regulatory (inhibitor) subunit 3C
    protein targeting to glycogen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051567.1 RefSeqGene

      Range
      5031..9660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005398.7NP_005389.1  protein phosphatase 1 regulatory subunit 3C

      See identical proteins and their annotated locations for NP_005389.1

      Status: REVIEWED

      Source sequence(s)
      AI766011, AK313149, BC012625, BP202053, H14591
      Consensus CDS
      CCDS7416.1
      UniProtKB/Swiss-Prot
      B2R7X0, O95686, Q9UQK1
      UniProtKB/TrEMBL
      B4DRR5, E7EMI6
      Related
      ENSP00000238994.5, ENST00000238994.6
      Conserved Domains (1) summary
      pfam03370
      Location:153256
      CBM_21; Carbohydrate/starch-binding module (family 21)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      91628442..91633071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      92511668..92516296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)