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    PARP3 poly(ADP-ribose) polymerase family member 3 [ Homo sapiens (human) ]

    Gene ID: 10039, updated on 3-Dec-2024

    Summary

    Official Symbol
    PARP3provided by HGNC
    Official Full Name
    poly(ADP-ribose) polymerase family member 3provided by HGNC
    Primary source
    HGNC:HGNC:273
    See related
    Ensembl:ENSG00000041880 MIM:607726; AllianceGenome:HGNC:273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3
    Summary
    The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PARP3 in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51942363..51948867)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51975282..51981786)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51976379..51982883)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:51935927-51937126 Neighboring gene IQ motif containing F1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51975282-51975930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19921 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51990057-51990645 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly(rC) binding protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51999749-52000312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52000313-52000874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52002001-52002564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52002565-52003126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52007254-52008190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19922 Neighboring gene abhydrolase domain containing 14B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD DNA ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein-lysine ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables catalytic activity TAS
    Traceable Author Statement
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein mono-ADP-ribosyltransferase PARP3
    Names
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3
    ADP-ribosyltransferase diphtheria toxin-like 3
    ADPRT-3
    DNA ADP-ribosyltransferase PARP3
    NAD(+) ADP-ribosyltransferase 3
    NAD+ ADP-ribosyltransferase 3
    poly [ADP-ribose] polymerase 3
    poly(ADP-ribose) synthetase-3
    poly[ADP-ribose] synthase 3
    poly[ADP-ribose] synthetase 3
    NP_001003931.4
    NP_001357168.1
    NP_001357169.1
    NP_005476.4
    XP_047303043.1
    XP_054200797.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003931.4NP_001003931.4  protein mono-ADP-ribosyltransferase PARP3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform b.
      Source sequence(s)
      CA309713, CA394313, Y16836
      Consensus CDS
      CCDS43097.1
      UniProtKB/Swiss-Prot
      Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
      UniProtKB/TrEMBL
      Q59HF6
      Related
      ENSP00000381740.4, ENST00000398755.8
      Conserved Domains (2) summary
      cd08002
      Location:58157
      WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
      cd01437
      Location:182532
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    2. NM_001370239.1NP_001357168.1  protein mono-ADP-ribosyltransferase PARP3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC115284, KF459622
      Consensus CDS
      CCDS43097.1
      UniProtKB/Swiss-Prot
      Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
      UniProtKB/TrEMBL
      Q59HF6
      Related
      ENSP00000395951.2, ENST00000417220.6
      Conserved Domains (2) summary
      cd08002
      Location:58157
      WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
      cd01437
      Location:182532
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    3. NM_001370240.1NP_001357169.1  protein mono-ADP-ribosyltransferase PARP3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC115284, KF459622
      Consensus CDS
      CCDS43097.1
      UniProtKB/Swiss-Prot
      Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
      UniProtKB/TrEMBL
      Q59HF6
      Related
      ENSP00000417396.2, ENST00000471971.6
      Conserved Domains (2) summary
      cd08002
      Location:58157
      WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
      cd01437
      Location:182532
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    4. NM_005485.6NP_005476.4  protein mono-ADP-ribosyltransferase PARP3 isoform a

      See identical proteins and their annotated locations for NP_005476.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      BI554046, CA309713, CA394313, Y16836
      Consensus CDS
      CCDS43097.1
      UniProtKB/Swiss-Prot
      Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
      UniProtKB/TrEMBL
      Q59HF6
      Related
      ENSP00000401511.1, ENST00000431474.6
      Conserved Domains (2) summary
      cd08002
      Location:58157
      WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
      cd01437
      Location:182532
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      51942363..51948867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447087.1XP_047303043.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

      UniProtKB/Swiss-Prot
      Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
      UniProtKB/TrEMBL
      Q59HF6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      51975282..51981786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344822.1XP_054200797.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

      UniProtKB/Swiss-Prot
      Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
      UniProtKB/TrEMBL
      Q59HF6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003935.2: Suppressed sequence

      Description
      NM_001003935.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.