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    RPP30 ribonuclease P/MRP subunit p30 [ Homo sapiens (human) ]

    Gene ID: 10556, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPP30provided by HGNC
    Official Full Name
    ribonuclease P/MRP subunit p30provided by HGNC
    Primary source
    HGNC:HGNC:17688
    See related
    Ensembl:ENSG00000148688 MIM:606115; AllianceGenome:HGNC:17688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSG15
    Summary
    Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 4.1), lymph node (RPKM 2.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPP30 in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (90871974..90908556)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (91755650..91792233)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (92631731..92668313)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3755 Neighboring gene 5-hydroxytryptamine receptor 7 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:92564844-92565562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2601 Neighboring gene Sharpr-MPRA regulatory region 7939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3757 Neighboring gene RNA, U6 small nuclear 740, pseudogene Neighboring gene ankyrin repeat domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38491

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonuclease P RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA 5'-leader removal IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ribonuclease P protein subunit p30
    Names
    RNase P subunit 2
    RNaseP protein p30
    ribonuclease P/MRP 30kDa subunit
    NP_001098016.1
    NP_006404.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104546.2NP_001098016.1  ribonuclease P protein subunit p30 isoform a

      See identical proteins and their annotated locations for NP_001098016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK095810, AL590622, BC044601, BM978236, DB049454, U77665
      Consensus CDS
      CCDS44458.1
      UniProtKB/Swiss-Prot
      P78346
      Related
      ENSP00000389182.1, ENST00000413330.5
      Conserved Domains (2) summary
      pfam01876
      Location:21224
      RNase_P_p30; RNase P subunit p30
      pfam13900
      Location:270299
      GVQW; Putative domain of unknown function
    2. NM_006413.5NP_006404.1  ribonuclease P protein subunit p30 isoform b

      See identical proteins and their annotated locations for NP_006404.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AL590622, AL833628, DB049454, U77665
      Consensus CDS
      CCDS7411.1
      UniProtKB/Swiss-Prot
      B2R799, E9PB02, P78346
      UniProtKB/TrEMBL
      Q5VU11
      Related
      ENSP00000360768.3, ENST00000371703.8
      Conserved Domains (1) summary
      pfam01876
      Location:21224
      RNase_P_p30; RNase P subunit p30

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      90871974..90908556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      91755650..91792233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)