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    ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) [ Homo sapiens (human) ]

    Gene ID: 957, updated on 9-Dec-2024

    Summary

    Official Symbol
    ENTPD5provided by HGNC
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 5 (inactive)provided by HGNC
    Primary source
    HGNC:HGNC:3367
    See related
    Ensembl:ENSG00000187097 MIM:603162; AllianceGenome:HGNC:3367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCPH; CD39L4; NTPDase-5
    Summary
    The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in liver (RPKM 43.1), colon (RPKM 29.4) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ENTPD5 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73955329..74019288, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68162983..68226953, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74422032..74485991, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74318268-74318670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8721 Neighboring gene prostaglandin reductase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8722 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74416687-74417687 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74418757-74419055 Neighboring gene coenzyme Q6, monooxygenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74459045-74459546 Neighboring gene Sharpr-MPRA regulatory region 8014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5926 Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene ribosomal protein L41 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36659 Neighboring gene basal body orientation factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74530601-74530820 Neighboring gene aldehyde dehydrogenase 6 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8725 Neighboring gene RNY4 pseudogene 21 Neighboring gene lin-52 DREAM MuvB core complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC163357, MGC163359

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables CDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables IDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables UDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables UDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect 'de novo' post-translational protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in UDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_positive_effect UDP-alpha-D-glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_positive_effect protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleoside diphosphate phosphatase ENTPD5
    Names
    CD39 antigen-like 4
    CD39-like 4
    ER-UDPase
    GDPase ENTPD5
    NTPDase 5
    Pcph proto-oncogene protein
    UDPase ENTPD5
    guanosine-diphosphatase ENTPD5
    inosine diphosphate phosphatase ENTPD5
    nucleoside diphosphatase
    proto-oncogene CPH
    uridine-diphosphatase ENTPD5
    NP_001240.1
    NP_001308913.1
    NP_001308914.1
    NP_001308915.1
    NP_001308916.1
    NP_001308917.1
    NP_001317118.1
    NP_001369185.1
    NP_001369186.1
    NP_001369187.1
    NP_001369188.1
    NP_001369189.1
    NP_001369191.1
    NP_001369192.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001249.5NP_001240.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001240.1

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Related
      ENSP00000335246.6, ENST00000334696.11
      Conserved Domains (1) summary
      cl17037
      Location:39424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_001321984.2NP_001308913.1  nucleoside diphosphate phosphatase ENTPD5 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Conserved Domains (1) summary
      cl17037
      Location:39400
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. NM_001321985.3NP_001308914.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. NM_001321986.3NP_001308915.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    5. NM_001321987.3NP_001308916.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    6. NM_001321988.3NP_001308917.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    7. NM_001330189.2NP_001317118.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484, AW028387
      Consensus CDS
      CCDS81825.1
      UniProtKB/TrEMBL
      G3V4I0
      Conserved Domains (1) summary
      cl17037
      Location:39404
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    8. NM_001382256.1NP_001369185.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    9. NM_001382257.1NP_001369186.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    10. NM_001382258.1NP_001369187.1  nucleoside diphosphate phosphatase ENTPD5 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Conserved Domains (1) summary
      cl17037
      Location:39410
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    11. NM_001382259.1NP_001369188.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS81825.1
      UniProtKB/TrEMBL
      G3V4I0
      Related
      ENSP00000451810.1, ENST00000557325.5
      Conserved Domains (1) summary
      cl17037
      Location:39404
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    12. NM_001382260.1NP_001369189.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS81825.1
      UniProtKB/TrEMBL
      G3V4I0
      Conserved Domains (1) summary
      cl17037
      Location:39404
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    13. NM_001382262.1NP_001369191.1  nucleoside diphosphate phosphatase ENTPD5 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Conserved Domains (1) summary
      cl17037
      Location:39396
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    14. NM_001382263.1NP_001369192.1  nucleoside diphosphate phosphatase ENTPD5 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Conserved Domains (1) summary
      cl17037
      Location:39377
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      73955329..74019288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      68162983..68226953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)