PAC11 dynein intermediate chain [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PAC11
Official Full Name: dynein intermediate chain
Primary source: SGD:S000002896
Locus tag: YDR488C
See related: AllianceGenome:SGD:S000002896; FungiDB:YDR488C; VEuPathDB:YDR488C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to plus-end-directed microtubule motor activity. Involved in establishment of mitotic spindle localization and nuclear migration along microtubule. Located in cytoplasmic microtubule. Part of cytoplasmic dynein complex. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PAC11 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1429188..1430789, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

interactions of a yeast ortholog of N-IC (N-Pac11) with yeast LC8 (Dyn2) or with the intermediate chain-binding subunit of yeast dynactin (Nip100).
Title: Interactions of Yeast Dynein with Dynein Light Chain and Dynactin: GENERAL IMPLICATIONS FOR INTRINSICALLY DISORDERED DUPLEX SCAFFOLDS IN MULTIPROTEIN ASSEMBLIES.
The Dyn2-Pac11 complex promotes Dyn1 homodimerization and potentiates processivity.
Title: The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization.
IC/Pac11 has a essential role in dynein function which providing new insight into the offloading model.
Title: The offloading model for dynein function: differential function of motor subunits.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to plus-end-directed microtubule motor activity	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to plus-end-directed microtubule motor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration along microtubule	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear migration along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein intermediate chain

NP_010776.1

Dynein intermediate chain, microtubule motor protein; required for intracellular transport and cell division; acts in cytoplasmic dynein pathway; forms complex with dynein light chain Dyn2p that promotes Dyn1p homodimerization and potentiates motor processivity; Dyn2p-Pac11p complex is also important for interaction of dynein motor complex with dynactin complex; forms cortical cytoplasmic microtubule capture site with Num1p; essential in the absence of CIN8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1429188..1430789 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180796.1 → NP_010776.1 TPA: dynein intermediate chain [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010776.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTB1, P40960, Q03398

UniProtKB/TrEMBL

C8Z646, N1P911

Conserved Domains (1) summary

pfam00400
Location:433 → 466

WD40; WD domain, G-beta repeat