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    GSTO1 glutathione S-transferase omega 1 [ Homo sapiens (human) ]

    Gene ID: 9446, updated on 9-Dec-2024

    Summary

    Official Symbol
    GSTO1provided by HGNC
    Official Full Name
    glutathione S-transferase omega 1provided by HGNC
    Primary source
    HGNC:HGNC:13312
    See related
    Ensembl:ENSG00000148834 MIM:605482; AllianceGenome:HGNC:13312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
    Summary
    The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GSTO1 in Genome Data Viewer
    Location:
    10q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (104254173..104267455)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (105142310..105155591)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106013931..106027213)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene tropomyosin 3 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1977 Neighboring gene microRNA 609 Neighboring gene Sharpr-MPRA regulatory region 2425 Neighboring gene uncharacterized LOC124902497 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106013818-106014332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3983 Neighboring gene microRNA 4482 Neighboring gene glutathione S-transferase omega 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:106058991-106060190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:106060509-106061008

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686H13163

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione dehydrogenase (ascorbate) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylarsonate reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    glutathione S-transferase omega-1
    Names
    MMA(V) reductase
    S-(Phenacyl)glutathione reductase
    epididymis secretory protein Li 21
    glutathione S-transferase omega 1-1
    glutathione-S-transferase like
    glutathione-dependent dehydroascorbate reductase
    monomethylarsonic acid reductase
    NP_001177931.1
    NP_001177932.1
    NP_004823.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023362.1 RefSeqGene

      Range
      5699..18262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001191002.2NP_001177931.1  glutathione S-transferase omega-1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CA431506, CN283947, DT220068
      Consensus CDS
      CCDS53572.1
      UniProtKB/TrEMBL
      Q5TA01
      Related
      ENSP00000358724.4, ENST00000369710.8
      Conserved Domains (3) summary
      cd03184
      Location:84196
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      COG0625
      Location:26177
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03055
      Location:594
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    2. NM_001191003.2NP_001177932.1  glutathione S-transferase omega-1 isoform 3

      See identical proteins and their annotated locations for NP_001177932.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL139341, CA431506, CF130513, DB501888
      Consensus CDS
      CCDS53573.1
      UniProtKB/TrEMBL
      Q5TA02
      Related
      ENSP00000441488.1, ENST00000539281.5
      Conserved Domains (3) summary
      PRK10542
      Location:12192
      PRK10542; glutathionine S-transferase; Provisional
      cd03184
      Location:80201
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cl00388
      Location:166
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    3. NM_004832.3NP_004823.1  glutathione S-transferase omega-1 isoform 1

      See identical proteins and their annotated locations for NP_004823.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BX537431
      Consensus CDS
      CCDS7555.1
      UniProtKB/Swiss-Prot
      D3DRA3, F5H7H0, P78417, Q5TA03, Q7Z3T2
      UniProtKB/TrEMBL
      B2R983, V9HWG9
      Related
      ENSP00000358727.5, ENST00000369713.10
      Conserved Domains (2) summary
      cd03184
      Location:108229
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:594
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      104254173..104267455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      105142310..105155591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)