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    RNF149 ring finger protein 149 [ Homo sapiens (human) ]

    Gene ID: 284996, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RNF149provided by HGNC
    Official Full Name
    ring finger protein 149provided by HGNC
    Primary source
    HGNC:HGNC:23137
    See related
    Ensembl:ENSG00000163162 AllianceGenome:HGNC:23137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DNAPTP2
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.1), appendix (RPKM 12.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF149 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101271219..101308701, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101729922..101767398, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101892063..101925163, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:101869253-101870165 Neighboring gene uncharacterized LOC105373511 Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene uncharacterized LOC124906052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11825 Neighboring gene uncharacterized LOC105373512 Neighboring gene microRNA 5696 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:101946330-101947106 and GRCh37_chr2:101947107-101947883 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101955361-101956145 Neighboring gene cellular repressor of E1A stimulated genes 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101986959-101987460 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. RNF167-mediated ubiquitination of Tollip inhibits TNF-α-triggered NF-κB and MAPK activation. Yan Z, et al. FASEB J, 2023 Aug. PMID 37410058
    2. Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF). Hong SW, et al. J Biol Chem, 2012 Jul 6. PMID 22628551, Free PMC Article
    3. Genome-wide association study of pancreatic cancer in Japanese population. Low SK, et al. PLoS One, 2010 Jul 29. PMID 20686608, Free PMC Article
    4. The role of RNF149 in the pre-emptive quality control substrate ubiquitination. Legesse A, et al. Commun Biol, 2023 Apr 8. PMID 37031316, Free PMC Article
    5. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that RNF149 (RING finger protein 149) interacts with wild-type BRAF.
      Title: Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF).
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of pancreatic cancer in Japanese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90504

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF149
    Names
    DNA polymerase-transactivated protein 2
    RING-type E3 ubiquitin transferase RNF149
    NP_775918.2
    XP_005263977.1
    XP_005263978.1
    XP_024308579.1
    XP_047299935.1
    XP_054197453.1
    XP_054197454.1
    XP_054197455.1
    XP_054197456.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173647.4 → NP_775918.2  E3 ubiquitin-protein ligase RNF149 precursor

      See identical proteins and their annotated locations for NP_775918.2

      Status: VALIDATED

      Source sequence(s)
      AC013722, AC073643, DA383672
      Consensus CDS
      CCDS2051.1
      UniProtKB/Swiss-Prot
      Q53S14, Q8N5I8, Q8NBY5, Q8NC42, Q8WUU3
      UniProtKB/TrEMBL
      F8WCD0
      Related
      ENSP00000295317.3, ENST00000295317.4
      Conserved Domains (3) summary
      cd02122
      Location:43 → 185
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:267 → 310
      zf-RING_2; Ring finger domain
      cl11506
      Location:204 → 235
      UPF0233; uncharacterized protein family (UPF0233)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      101271219..101308701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263921.5 → XP_005263978.1  E3 ubiquitin-protein ligase RNF149 isoform X2

      UniProtKB/TrEMBL
      F8WCD0
      Conserved Domains (3) summary
      cd02122
      Location:43 → 185
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:267 → 310
      zf-RING_2; Ring finger domain
      cl11506
      Location:204 → 235
      UPF0233; uncharacterized protein family (UPF0233)

    2. XM_024452811.2 → XP_024308579.1  E3 ubiquitin-protein ligase RNF149 isoform X3

      UniProtKB/TrEMBL
      F8WCD0
      Conserved Domains (2) summary
      cd02122
      Location:43 → 185
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16804
      Location:268 → 315
      RING-H2_RNF149; RING finger, H2 subclass, found in RING finger protein 149 (RNF149) and similar proteins

    3. XM_005263920.4 → XP_005263977.1  E3 ubiquitin-protein ligase RNF149 isoform X1

      UniProtKB/TrEMBL
      F8WCD0
      Conserved Domains (3) summary
      cd02122
      Location:43 → 185
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:267 → 310
      zf-RING_2; Ring finger domain
      cl11506
      Location:204 → 235
      UPF0233; uncharacterized protein family (UPF0233)

    4. XM_047443979.1 → XP_047299935.1  E3 ubiquitin-protein ligase RNF149 isoform X4

    RNA

    1. XR_001738712.3 RNA Sequence

    2. XR_922908.3 RNA Sequence

      Related
      ENST00000424632.5

    3. XR_922909.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      101729922..101767398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341479.1 → XP_054197454.1  E3 ubiquitin-protein ligase RNF149 isoform X2

      UniProtKB/TrEMBL
      F8WCD0

    2. XM_054341480.1 → XP_054197455.1  E3 ubiquitin-protein ligase RNF149 isoform X3

      UniProtKB/TrEMBL
      F8WCD0

    3. XM_054341478.1 → XP_054197453.1  E3 ubiquitin-protein ligase RNF149 isoform X1

      UniProtKB/TrEMBL
      F8WCD0

    4. XM_054341481.1 → XP_054197456.1  E3 ubiquitin-protein ligase RNF149 isoform X4

    RNA

    1. XR_008486330.1 RNA Sequence

    2. XR_008486331.1 RNA Sequence

    3. XR_008486332.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NC42.2 GenPept UniProtKB/Swiss-Prot:Q8NC42

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