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    DCST1-AS1 DCST1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100505666, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DCST1-AS1provided by HGNC
    Official Full Name
    DCST1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:41147
    See related
    Ensembl:ENSG00000232093 AllianceGenome:HGNC:41147
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in skin (RPKM 2.7), colon (RPKM 1.3) and 23 other tissues See more
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    Genomic context

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    See DCST1-AS1 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155045191..155063991, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154184567..154203378, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155017667..155036467, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154977250-154977922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154980166-154980880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154982382-154983131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154984631-154985378 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:154989823 Neighboring gene DC-STAMP domain containing 2 Neighboring gene DC-STAMP domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1383 Neighboring gene ADAM15-EFNA4 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155029213-155030023 Neighboring gene ADAM metallopeptidase domain 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1386 Neighboring gene NANOG hESC enhancer GRCh37_chr1:155037167-155037668 Neighboring gene EFNA4-EFNA3 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155041991-155042503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155043017-155043529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155044044-155044556 Neighboring gene ephrin A4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1391 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155058284-155058452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1392 Neighboring gene ephrin A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155065994-155066608 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155075818-155075984 Neighboring gene Sharpr-MPRA regulatory region 6409 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155098207-155099046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1393 Neighboring gene ephrin A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-κB Signaling. Ai Y, et al. J Immunol Res, 2021. PMID 34414241, Free PMC Article
    2. LncRNA DCST1-AS1 accelerates the proliferation, metastasis and autophagy of hepatocellular carcinoma cell by AKT/mTOR signaling pathways. Li J, et al. Eur Rev Med Pharmacol Sci, 2019 Jul. PMID 31364110
    3. LncRNA DCST1-AS1 drives the malignant progression of pediatric acute myeloid leukemia via regulating p53 methylation. Wang J, et al. Cell Mol Biol (Noisy-le-grand), 2023 Nov 30. PMID 38063091
    4. Inhibition of lncRNA DCST1-AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression. Liu J, et al. J Gene Med, 2021 Jan. PMID 33025624
    5. LncRNA DCST1-AS1 functions as a competing endogenous RNA to regulate FAIM2 expression by sponging miR-1254 in hepatocellular carcinoma. Chen J, et al. Clin Sci (Lond), 2019 Jan 31. PMID 30617187

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA DCST1-AS1 drives the malignant progression of pediatric acute myeloid leukemia via regulating p53 methylation.
      Title: LncRNA DCST1-AS1 drives the malignant progression of pediatric acute myeloid leukemia via regulating p53 methylation.
    2. lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-kappaB Signaling.
      Title: lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-κB Signaling.
    3. Inhibition of lncRNA DCST1-AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression.
      Title: Inhibition of lncRNA DCST1-AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression.
    4. LncRNA DCST1-AS1 accelerates the proliferation, metastasis and autophagy of hepatocellular carcinoma cell by AKT/mTOR signaling pathways.
      Title: LncRNA DCST1-AS1 accelerates the proliferation, metastasis and autophagy of hepatocellular carcinoma cell by AKT/mTOR signaling pathways.
    5. DCST1-AS1 up-regulates the expression of FAIM2 by up-regulating the expression of miR-1254, ultimately promoting the proliferation of hepatocellular carcinoma cells.
      Title: LncRNA DCST1-AS1 functions as a competing endogenous RNA to regulate FAIM2 expression by sponging miR-1254 in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • RP11-307C12.11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_040772.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      BU634037, BX114680, BX363279, DA951851
      Related
      ENST00000452962.2

    2. NR_040773.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate splice site in the 3' region, compared to variant 1.
      Source sequence(s)
      BM047608, BU634037, DB152307

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      155045191..155063991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      154184567..154203378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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