GNB1 G protein subunit beta 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GNB1provided by HGNC
Official Full Name: G protein subunit beta 1provided by HGNC
Primary source: HGNC:HGNC:4396
See related: Ensembl:ENSG00000078369 MIM:139380; AllianceGenome:HGNC:4396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MDS; HG2A; MRD42
Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression: Ubiquitous expression in brain (RPKM 145.4), small intestine (RPKM 87.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.33

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (1785286..1891087, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (1219664..1325475, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (1716725..1822526, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GNB1 and obesity: Evidence for a correlation between haploinsufficiency and syndromic obesity.
Title: GNB1 and obesity: Evidence for a correlation between haploinsufficiency and syndromic obesity.
Atypical clinical course in two patients with GNB1 variants who developed acute encephalopathy.
Title: Atypical clinical course in two patients with GNB1 variants who developed acute encephalopathy.
G Protein Subunit beta1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2.
Title: G Protein Subunit β1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2.
AFAP1 antisense RNA 1 promotes retinoblastoma progression by sponging microRNA miR-545-3p that targets G protein subunit beta 1.
Title: AFAP1 antisense RNA 1 promotes retinoblastoma progression by sponging microRNA miR-545-3p that targets G protein subunit beta 1.
Shikonin induces cell autophagy via modulating the microRNA -545-3p/guanine nucleotide binding protein beta polypeptide 1 axis, thereby disrupting cellular carcinogenesis in colon cancer.
Title: Shikonin induces cell autophagy via modulating the microRNA -545-3p/guanine nucleotide binding protein beta polypeptide 1 axis, thereby disrupting cellular carcinogenesis in colon cancer.
Gbetagamma translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.
Title: Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.
Genotype-phenotype correlation in GNB1-related neurodevelopmental disorder: Potential association of p.Leu95Pro with cleft palate.
Title: Genotype-phenotype correlation in GNB1-related neurodevelopmental disorder: Potential association of p.Leu95Pro with cleft palate.
In the new cohort of 18 patients, 50% of males had genitourinary anomalies and 61% of patients had gastrointestinal anomalies, suggesting a possible association of these findings with variants in GNB1.
Title: Refining the phenotype associated with GNB1 mutations: Clinical data on 18 newly identified patients and review of the literature.
Mutation in the GNB1 gene is associated with neurodevelopmental disorder and cutaneous mastocytosis.
Title: Novel GNB1 de novo mutation in a patient with neurodevelopmental disorder and cutaneous mastocytosis: Clinical report and literature review.
Through analysis of the genomic and proteomic profiles of resistant cells, we identified an acquired mutation in the GNB1 gene, K89M, as the most likely cause of the resistance
Title: An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Acute lymphoid leukemia MedGen: C0023449 OMIM: 613065 GeneReviews: Not available	not available
Intellectual disability, autosomal dominant 42 MedGen: C4310774 OMIM: 616973 GeneReviews: GNB1 Encephalopathy	not available
Myelodysplastic syndrome MedGen: C3463824 OMIM: 614286 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2019-01-23) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2019-01-23) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1) in the nucleoli of Jurkat T-cells	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of guanine nucleotide binding protein, beta polypeptide 1 (GNB1) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH64187 (e-PCR)
- UniSTS:67622

GNB1_444 (e-PCR)
- UniSTS:277289

D14S930 (e-PCR)
- UniSTS:54876

SHGC-74116 (e-PCR)
- UniSTS:16765

SHGC-74103 (e-PCR)
- UniSTS:54459

SHGC-74079 (e-PCR)
- UniSTS:49619

RH78938 (e-PCR)
- UniSTS:57560

NoName (e-PCR)
- UniSTS:489701

PMC197251P1 (e-PCR)
- UniSTS:271850

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to catecholamine stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to prostaglandin E stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular vesicle	HDA more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	HDA more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor disc membrane	TAS Traceable Author Statement more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Names: beta subunit, signal-transducing proteins GS/GI; guanine nucleotide binding protein (G protein), beta polypeptide 1; heterotrimeric guanine nucleotide-binding protein 2A; testicular tissue protein Li 72; transducin beta chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047052.1 RefSeqGene

Range

5031..110832

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001282538.2 → NP_001269467.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 2

See identical proteins and their annotated locations for NP_001269467.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AI092255, AK122949, BC004186, BQ881467

Consensus CDS

CCDS72685.1

UniProtKB/TrEMBL

B3KVK2, Q71UM6

Related

ENSP00000483532.1, ENST00000615252.5

Conserved Domains (2) summary

cd00200
Location:2 → 240

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:1 → 41

7WD40; WD40 repeat [structural motif]
NM_001282539.2 → NP_001269468.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1

See identical proteins and their annotated locations for NP_001269468.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AI092255, BC004186, BU902364

Consensus CDS

CCDS34.1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000481878.1, ENST00000610897.4

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
NM_002074.5 → NP_002065.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1

See identical proteins and their annotated locations for NP_002065.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AI092255, BC004186, BQ881467

Consensus CDS

CCDS34.1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000367872.3, ENST00000378609.9

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

1785286..1891087 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418078.1 → XP_047274034.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5
XM_047418076.1 → XP_047274032.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5

Related

ENSP00000515441.1, ENST00000703707.1
XM_017001061.3 → XP_016856550.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_047418072.1 → XP_047274028.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5

Related

ENSP00000399741.3, ENST00000439272.7
XM_017001060.3 → XP_016856549.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_047418073.1 → XP_047274029.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5
XM_047418070.1 → XP_047274026.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418049.1 → XP_047274005.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000515440.1, ENST00000703706.1
XM_047418071.1 → XP_047274027.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418061.1 → XP_047274017.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418054.1 → XP_047274010.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418042.1 → XP_047273998.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000515443.1, ENST00000703709.1
XM_047418059.1 → XP_047274015.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418050.1 → XP_047274006.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418057.1 → XP_047274013.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418044.1 → XP_047274000.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418046.1 → XP_047274002.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418045.1 → XP_047274001.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_024446495.2 → XP_024302263.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000515434.1, ENST00000703700.1

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_047418058.1 → XP_047274014.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000515428.1, ENST00000703693.1
XM_047418068.1 → XP_047274024.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000515432.1, ENST00000703697.1
XM_047418056.1 → XP_047274012.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000515442.1, ENST00000703708.1
XM_047418074.1 → XP_047274030.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5
XM_047418055.1 → XP_047274011.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418062.1 → XP_047274018.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418043.1 → XP_047273999.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000515435.1, ENST00000703701.1
XM_047418069.1 → XP_047274025.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418063.1 → XP_047274019.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_047418060.1 → XP_047274016.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Related

ENSP00000515438.1, ENST00000703704.1
XM_047418067.1 → XP_047274023.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_017001059.3 → XP_016856548.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

1219664..1325475 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336086.1 → XP_054192061.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5
XM_054336085.1 → XP_054192060.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5
XM_054336079.1 → XP_054192054.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336082.1 → XP_054192057.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5
XM_054336073.1 → XP_054192048.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336083.1 → XP_054192058.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5
XM_054336077.1 → XP_054192052.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336061.1 → XP_054192036.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336078.1 → XP_054192053.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336070.1 → XP_054192045.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336063.1 → XP_054192038.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336055.1 → XP_054192030.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336068.1 → XP_054192043.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336062.1 → XP_054192037.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336066.1 → XP_054192041.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336058.1 → XP_054192033.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336060.1 → XP_054192035.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336059.1 → XP_054192034.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336056.1 → XP_054192031.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336067.1 → XP_054192042.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336075.1 → XP_054192050.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336065.1 → XP_054192040.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336084.1 → XP_054192059.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A2L0WW42, F6X3N5
XM_054336064.1 → XP_054192039.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336071.1 → XP_054192046.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336057.1 → XP_054192032.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336076.1 → XP_054192051.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336072.1 → XP_054192047.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336069.1 → XP_054192044.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336074.1 → XP_054192049.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336080.1 → XP_054192055.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42
XM_054336081.1 → XP_054192056.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

B1AJZ7, P04697, P04901, P62873, Q1RMY8

UniProtKB/TrEMBL

A0A024R056, A0A140VJJ8, A0A2L0WW42