U.S. flag

An official website of the United States government

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

Links from GEO Profiles

    • Showing Current items.

    SMAD3 SMAD family member 3 [ Homo sapiens (human) ]

    Gene ID: 4088, updated on 4-Jan-2025

    Summary

    Official Symbol
    SMAD3provided by HGNC
    Official Full Name
    SMAD family member 3provided by HGNC
    Primary source
    HGNC:HGNC:6769
    See related
    Ensembl:ENSG00000166949 MIM:603109; AllianceGenome:HGNC:6769
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LDS3; mad3; LDS1C; MADH3; JV15-2; hMAD-3; hSMAD3; HSPC193; HsT17436
    Summary
    The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 13.6), ovary (RPKM 13.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SMAD3 in Genome Data Viewer
    Location:
    15q22.33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (67065602..67195169)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (64885345..65017070)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (67357940..67487507)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9309 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:67248284-67249483 Neighboring gene SMAD3 associated long non-coding RNA Neighboring gene ReSE screen-validated silencer GRCh37_chr15:67287649-67287867 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:67300958-67301136 Neighboring gene SMAD3 divergent transcript Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40591 Neighboring gene Sharpr-MPRA regulatory region 4683 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67322513-67323169 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 47 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67325333-67325940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67325941-67326548 Neighboring gene HNF4 motif-containing MPRA enhancer 189 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:67356188-67356958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:67358498-67359266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9620 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67381826-67382343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67382344-67382860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67386222-67386992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:67390571-67391072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67398175-67398874 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:67399127-67400326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67412437-67413294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9624 Neighboring gene FOXA motif-containing MPRA enhancer 105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67438421-67439356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67439357-67440291 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67440670-67441477 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:67442285-67443092 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40599 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40600 Neighboring gene SMAD3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67459191-67459860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:67460533-67461202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:67459861-67460532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9628 Neighboring gene alpha and gamma adaptin binding protein Neighboring gene ribosomal protein S24 pseudogene 16 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:67569773-67569933 Neighboring gene IQ motif containing H Neighboring gene VISTA enhancer hs358 Neighboring gene Sharpr-MPRA regulatory region 12968 Neighboring gene IQCH antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 13361 Neighboring gene uncharacterized LOC124903511

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (21 hits/1409 screens)

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in SMAD3 that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2020-04-22)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2020-04-22)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.
    EBI GWAS Catalog
    A large-scale, consortium-based genomewide association study of asthma.
    EBI GWAS Catalog
    Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Genomewide association analysis of coronary artery disease.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-treated pulmonary arterial smooth muscle cells downregulate levels of phosphorylated SMAD2/3 proteins and SMAD2/3-SMAD4 protein complex, which are repressed by cocaine exposure PubMed
    tat HIV-1 Tat enhances binding of SMAD2, -3 and -4 and their binding partner Fast1 to the JCV DNA control region (CR) to stimulate JCV gene transcription in living cells PubMed
    tat The C-terminal MH2 domain of Smad3 can decrease the levels of HIV-1 Tat-induced activation of MCP-1 in astrocytic cells PubMed
    tat Smad-3 stimulates HIV-1 Tat mediated transcription from the HIV-1 LTR promoter and the MCP promoter through a direct association with Tat amino acids 1-40 PubMed
    Vpr vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC60396, DKFZp586N0721, DKFZp686J10186

    Gene Ontology Provided by GOA

    Items 1 - 25 of 44
    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding PubMed 
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    contributes_to DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding PubMed 
    enables DNA-binding transcription repressor activity PubMed 
    enables I-SMAD binding  
    enables R-SMAD binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables bHLH transcription factor binding PubMed 
    enables beta-catenin binding  
    enables chromatin DNA binding  
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables co-SMAD binding PubMed 
    enables collagen binding  
    enables identical protein binding PubMed 
    enables nuclear glucocorticoid receptor binding PubMed 
    enables nuclear mineralocorticoid receptor binding PubMed 
    enables nuclear receptor binding PubMed 
    enables phosphatase binding PubMed 
    enables promoter-specific chromatin binding  
    enables protein binding PubMed 
    enables protein homodimerization activity PubMed 
    enables protein kinase binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sterol response element binding PubMed 
    enables transcription cis-regulatory region binding PubMed 
    enables transcription coactivator binding PubMed 
    enables transcription corepressor binding PubMed 
    enables transforming growth factor beta receptor binding PubMed 
    enables ubiquitin binding PubMed 
    enables ubiquitin protein ligase binding PubMed 
    enables zinc ion binding PubMed 
    Items 1 - 25 of 44
    Items 1 - 25 of 100
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in SMAD protein signal transduction  
    involved_in SMAD protein signal transduction PubMed 
    acts_upstream_of SMAD protein signal transduction PubMed 
    involved_in SMAD protein signal transduction PubMed 
    involved_in T cell activation  
    involved_in activin receptor signaling pathway  
    involved_in activin receptor signaling pathway PubMed 
    involved_in activin receptor signaling pathway PubMed 
    involved_in adrenal gland development  
    involved_in anatomical structure morphogenesis  
    involved_in apoptotic signaling pathway PubMed 
    involved_in cell differentiation  
    involved_in cell population proliferation  
    involved_in cell-cell junction organization PubMed 
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to virus  
    involved_in developmental growth  
    involved_in embryonic cranial skeleton morphogenesis  
    involved_in embryonic foregut morphogenesis  
    involved_in embryonic pattern specification  
    involved_in endoderm development  
    involved_in extrinsic apoptotic signaling pathway PubMed 
    involved_in heart looping  
    involved_in immune response PubMed 
    involved_in immune system development  
    involved_in in utero embryonic development  
    involved_in lens fiber cell differentiation  
    involved_in liver development  
    involved_in mesoderm formation  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress  
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration PubMed 
    involved_in negative regulation of fat cell differentiation PubMed 
    acts_upstream_of negative regulation of gene expression PubMed 
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of lung blood pressure  
    involved_in negative regulation of miRNA transcription PubMed 
    involved_in negative regulation of ossification PubMed 
    involved_in negative regulation of osteoblast differentiation  
    involved_in negative regulation of osteoblast proliferation  
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of wound healing  
    involved_in nodal signaling pathway PubMed 
    involved_in osteoblast development  
    involved_in paraxial mesoderm morphogenesis  
    involved_in pericardium development  
    involved_in positive regulation of DNA-binding transcription factor activity PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of chondrocyte differentiation  
    involved_in positive regulation of epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of extracellular matrix assembly PubMed 
    acts_upstream_of positive regulation of extracellular matrix assembly PubMed 
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of miRNA transcription PubMed 
    acts_upstream_of positive regulation of miRNA transcription PubMed 
    involved_in positive regulation of miRNA transcription PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process PubMed 
    involved_in positive regulation of positive chemotaxis  
    involved_in positive regulation of protein import into nucleus PubMed 
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transforming growth factor beta3 production  
    involved_in primary miRNA processing PubMed 
    involved_in protein stabilization  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of epithelial cell proliferation  
    involved_in regulation of immune response  
    involved_in regulation of miRNA transcription PubMed 
    involved_in regulation of striated muscle tissue development  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway  
    involved_in regulation of transforming growth factor beta2 production PubMed 
    acts_upstream_of response to angiotensin PubMed 
    involved_in response to hypoxia PubMed 
    involved_in signal transduction involved in regulation of gene expression  
    involved_in somitogenesis  
    involved_in thyroid gland development  
    involved_in transdifferentiation  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    involved_in ureteric bud development  
    involved_in wound healing PubMed 
    Items 1 - 25 of 100
    Component Evidence Code Pubs
    part_of SMAD protein complex PubMed 
    located_in chromatin PubMed 
    located_in chromatin  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    part_of heteromeric SMAD protein complex  
    part_of heteromeric SMAD protein complex PubMed 
    part_of heteromeric SMAD protein complex PubMed 
    located_in nuclear inner membrane PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in plasma membrane  
    part_of receptor complex PubMed 
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 3
    Names
    MAD homolog 3
    MAD, mothers against decapentaplegic homolog 3
    SMA- and MAD-related protein 3
    SMAD, mothers against DPP homolog 3
    mad homolog JV15-2
    mad protein homolog
    mothers against DPP homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011990.2 RefSeqGene

      Range
      5002..134569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145102.2 → NP_001138574.1  mothers against decapentaplegic homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_001138574.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC012568
      Consensus CDS
      CCDS53950.1
      UniProtKB/TrEMBL
      H3BVD1
      Related
      ENSP00000437757.2, ENST00000540846.6
      Conserved Domains (2) summary
      cd10985
      Location:119 → 309
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
      cl00055
      Location:1 → 27
      MH1; N-terminal Mad Homology 1 (MH1) domain
    2. NM_001145103.2 → NP_001138575.1  mothers against decapentaplegic homolog 3 isoform 3

      See identical proteins and their annotated locations for NP_001138575.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC012568
      Consensus CDS
      CCDS45288.1
      UniProtKB/TrEMBL
      Q59F45
      Related
      ENSP00000401133.3, ENST00000439724.7
      Conserved Domains (2) summary
      cd10985
      Location:180 → 370
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
      cl00055
      Location:25 → 88
      MH1; N-terminal Mad Homology 1 (MH1) domain
    3. NM_001145104.2 → NP_001138576.1  mothers against decapentaplegic homolog 3 isoform 4

      See identical proteins and their annotated locations for NP_001138576.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC012568
      Consensus CDS
      CCDS53951.1
      UniProtKB/TrEMBL
      B7Z725
      Related
      ENSP00000445348.2, ENST00000537194.6
      Conserved Domains (1) summary
      cd10985
      Location:29 → 219
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    4. NM_001407011.1 → NP_001393940.1  mothers against decapentaplegic homolog 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC012568, AC087482
      UniProtKB/TrEMBL
      A0AAQ5BHK2, H3BQ00
      Related
      ENSP00000455540.2, ENST00000560424.2
    5. NM_001407012.1 → NP_001393941.1  mothers against decapentaplegic homolog 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC012568, AC087482
      UniProtKB/TrEMBL
      A0AAQ5BHI7, A0AAQ5BHK2
      Related
      ENSP00000519401.1, ENST00000714109.1
    6. NM_001407013.1 → NP_001393942.1  mothers against decapentaplegic homolog 3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC012568, AC087482
      UniProtKB/TrEMBL
      A0AAQ5BHK2
      Related
      ENSP00000519400.1, ENST00000714108.1
    7. NM_001407014.1 → NP_001393943.1  mothers against decapentaplegic homolog 3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC012568, AC087482
      UniProtKB/TrEMBL
      Q59F45
    8. NM_001407015.1 → NP_001393944.1  mothers against decapentaplegic homolog 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC012568
      UniProtKB/TrEMBL
      H3BVD1
    9. NM_001407016.1 → NP_001393945.1  mothers against decapentaplegic homolog 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC012568
      UniProtKB/TrEMBL
      H3BVD1
      Related
      ENSP00000453684.2, ENST00000558739.2
    10. NM_001407017.1 → NP_001393946.1  mothers against decapentaplegic homolog 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC012568
      UniProtKB/TrEMBL
      B7Z725
      Related
      ENSP00000452767.2, ENST00000558827.2
    11. NM_005902.4 → NP_005893.1  mothers against decapentaplegic homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_005893.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC012568, AC087482
      Consensus CDS
      CCDS10222.1
      UniProtKB/Swiss-Prot
      A8K4B6, B7Z4Z5, B7Z6M9, B7Z9Q2, F5H383, O09064, O09144, O14510, O35273, P84022, Q92940, Q93002, Q9GKR4
      UniProtKB/TrEMBL
      A0AAQ5BHK2
      Related
      ENSP00000332973.4, ENST00000327367.9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 132
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:224 → 414
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      67065602..67195169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      64885345..65017070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377915.1 → XP_054233890.1  mothers against decapentaplegic homolog 3 isoform X2

      UniProtKB/TrEMBL
      H3BVD1
    2. XM_054377914.1 → XP_054233889.1  mothers against decapentaplegic homolog 3 isoform X1

      UniProtKB/TrEMBL
      Q59F45
    External link. Please review our privacy policy.