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    SOCS2 suppressor of cytokine signaling 2 [ Homo sapiens (human) ]

    Gene ID: 8835, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SOCS2provided by HGNC
    Official Full Name
    suppressor of cytokine signaling 2provided by HGNC
    Primary source
    HGNC:HGNC:19382
    See related
    Ensembl:ENSG00000120833 MIM:605117; AllianceGenome:HGNC:19382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2
    Summary
    This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in endometrium (RPKM 13.5), prostate (RPKM 10.5) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SOCS2 in Genome Data Viewer
    Location:
    12q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (93569969..93626236)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (93551422..93607676)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93963745..93970521)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene RNA, 7SL, cytoplasmic 737, pseudogene Neighboring gene uncharacterized LOC124902985 Neighboring gene MPRA-validated peak1894 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:93975910-93976410 Neighboring gene SOCS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:93976411-93976911 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93977698-93978644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93978645-93979590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93984897-93985456 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:94018330-94019529 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:94070392-94071207 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:94071208-94072022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:94072839-94073653 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:94092983-94093855 Neighboring gene CASP2 and RIPK1 domain containing adaptor with death domain Neighboring gene CRADD antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging. Noroozi R, et al. Geroscience, 2024 Apr. PMID 38103096, Free PMC Article
    2. Genetic predictors of long-term response to growth hormone (GH) therapy in children with GH deficiency and Turner syndrome: the influence of a SOCS2 polymorphism. Braz AF, et al. J Clin Endocrinol Metab, 2014 Sep. PMID 24905066
    3. High expression of suppressor of cytokine signaling-2 predicts poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Laszlo GS, et al. Leuk Lymphoma, 2014 Dec. PMID 24559289, Free PMC Article
    4. SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer. Hoefer J, et al. Endocr Relat Cancer, 2014 Apr. PMID 24280133, Free PMC Article
    5. Dopaminergic activity and behaviour in SOCS2 transgenic mice: Revealing a potential drug target for schizophrenia. Ratnayake U, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2015 Jan 2. PMID 25283341

    See all (160) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of SOCS2 Inhibits EMT and M2 Macrophage Polarization in Cervical Cancer via IL-6/JAK2/STAT3 Pathway.
      Title: Overexpression of SOCS2 Inhibits EMT and M2 Macrophage Polarization in Cervical Cancer via IL-6/JAK2/STAT3 Pathway.
    2. Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging.
      Title: Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging.
    3. Inhibition of miR-578 through SOCS2-dependent manner reverses gefitinib resistance in NSCLC cells.
      Title: Inhibition of miR-578 through SOCS2-dependent manner reverses gefitinib resistance in NSCLC cells.
    4. SOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway.
      Title: SOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway.
    5. CTRP6 protects against ferroptosis to drive lung cancer progression and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4 pathway.
      Title: CTRP6 protects against ferroptosis to drive lung cancer progression and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4 pathway.
    6. MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3A.
      Title: MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3A.
    7. Upregulation of SOCS2 causes mitochondrial dysfunction and promotes ferroptosis in pancreatic cancer cells.
      Title: Upregulation of SOCS2 causes mitochondrial dysfunction and promotes ferroptosis in pancreatic cancer cells.
    8. circ_0008797 attenuates non-small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR-301a-3p/SOCS2.
      Title: circ_0008797 attenuates non-small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR-301a-3p/SOCS2.
    9. miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2).
      Title: miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2).
    10. MicroRNA -196b is related to the overall survival of patients with esophageal squamous cell carcinoma and facilitates tumor progression by regulating SOCS2 (Suppressor Of Cytokine Signaling 2).
      Title: MicroRNA -196b is related to the overall survival of patients with esophageal squamous cell carcinoma and facilitates tumor progression by regulating SOCS2 (Suppressor Of Cytokine Signaling 2).
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide analysis of hepatic lipid content in extreme obesity.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 20 loci that influence adult height.
    EBI GWAS Catalog
    Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of suppressor of cytokine signaling 2 (SOCS2) in human primary T cells PubMed
    tat HIV-1 Tat impairs the IFNgamma-receptor signaling pathway in primary human monocytes at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables JAK pathway signal transduction adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cytokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth hormone receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables insulin-like growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphorylation-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hormone stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to estradiol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 2
    Names
    CIS-2
    STAT-induced STAT inhibitor 2
    cytokine-inducible SH2 protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270467.2 → NP_001257396.1  suppressor of cytokine signaling 2

      See identical proteins and their annotated locations for NP_001257396.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
      Source sequence(s)
      AC012085, AI129818, AK313165, BC010399, BJ996504, CD699665, DA709082
      Consensus CDS
      CCDS9047.1
      UniProtKB/Swiss-Prot
      A8K3D1, O14508, O14542, O95102, Q9UKS5
      UniProtKB/TrEMBL
      B5BU82
      Related
      ENSP00000448815.1, ENST00000549206.5
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 198
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    2. NM_001270468.2 → NP_001257397.1  suppressor of cytokine signaling 2

      See identical proteins and their annotated locations for NP_001257397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI129818, AK313165, BC010399, BJ996504, CD699665, DA490057
      Consensus CDS
      CCDS9047.1
      UniProtKB/Swiss-Prot
      A8K3D1, O14508, O14542, O95102, Q9UKS5
      UniProtKB/TrEMBL
      B5BU82
      Related
      ENSP00000442898.2, ENST00000536696.6
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 198
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    3. NM_001270469.2 → NP_001257398.1  suppressor of cytokine signaling 2

      See identical proteins and their annotated locations for NP_001257398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI129818, AK313165, BC010399, BJ996504, CD699665, DB054162
      Consensus CDS
      CCDS9047.1
      UniProtKB/Swiss-Prot
      A8K3D1, O14508, O14542, O95102, Q9UKS5
      UniProtKB/TrEMBL
      B5BU82
      Related
      ENSP00000447161.1, ENST00000549122.5
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 198
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    4. NM_001270470.1 → NP_001257399.1  suppressor of cytokine signaling 2

      See identical proteins and their annotated locations for NP_001257399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI129818, AK313165, BC010399, BJ996504, CD699665, DB054162, DB481261
      Consensus CDS
      CCDS9047.1
      UniProtKB/Swiss-Prot
      A8K3D1, O14508, O14542, O95102, Q9UKS5
      UniProtKB/TrEMBL
      B5BU82
      Related
      ENSP00000481249.1, ENST00000622746.4
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 198
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    5. NM_001270471.2 → NP_001257400.1  suppressor of cytokine signaling 2

      See identical proteins and their annotated locations for NP_001257400.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI129818, AK313165, BC010399, BJ996504, CD699665, DC300183
      Consensus CDS
      CCDS9047.1
      UniProtKB/Swiss-Prot
      A8K3D1, O14508, O14542, O95102, Q9UKS5
      UniProtKB/TrEMBL
      B5BU82
      Related
      ENSP00000449227.1, ENST00000551556.2
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 198
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    6. NM_003877.5 → NP_003868.1  suppressor of cytokine signaling 2

      See identical proteins and their annotated locations for NP_003868.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI129818, AK313165, AL522912, BC010399, BJ996504, CD699665
      Consensus CDS
      CCDS9047.1
      UniProtKB/Swiss-Prot
      A8K3D1, O14508, O14542, O95102, Q9UKS5
      UniProtKB/TrEMBL
      B5BU82
      Related
      ENSP00000339428.2, ENST00000340600.6
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 198
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      93569969..93626236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020147.2 → XP_016875636.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    2. XM_017020152.2 → XP_016875641.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    3. XM_047429808.1 → XP_047285764.1  suppressor of cytokine signaling 2 isoform X6

      UniProtKB/Swiss-Prot
      A8K3D1, O14508, O14542, O95102, Q9UKS5
      UniProtKB/TrEMBL
      B5BU82

    4. XM_017020148.3 → XP_016875637.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    5. XM_017020151.2 → XP_016875640.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    6. XM_047429807.1 → XP_047285763.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    7. XM_017020149.2 → XP_016875638.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    8. XM_011538935.2 → XP_011537237.1  suppressor of cytokine signaling 2 isoform X4

      UniProtKB/TrEMBL
      B5BU82
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 198
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    9. XM_011538936.2 → XP_011537238.1  suppressor of cytokine signaling 2 isoform X5

      UniProtKB/TrEMBL
      B5BU82
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 197
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    10. XM_011538929.2 → XP_011537231.1  suppressor of cytokine signaling 2 isoform X3

      See identical proteins and their annotated locations for XP_011537231.1

      UniProtKB/TrEMBL
      B5BU82
      Conserved Domains (2) summary
      cd10383
      Location:40 → 142
      SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03736
      Location:158 → 197
      SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

    11. XM_017020155.3 → XP_016875644.1  suppressor of cytokine signaling 2 isoform X2

      UniProtKB/TrEMBL
      B5BU82

    RNA

    1. XR_944810.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      93551422..93607676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373709.1 → XP_054229684.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    2. XM_054373713.1 → XP_054229688.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    3. XM_054373710.1 → XP_054229685.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    4. XM_054373712.1 → XP_054229687.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    5. XM_054373711.1 → XP_054229686.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    6. XM_054373716.1 → XP_054229691.1  suppressor of cytokine signaling 2 isoform X4

      UniProtKB/TrEMBL
      B5BU82

    7. XM_054373717.1 → XP_054229692.1  suppressor of cytokine signaling 2 isoform X5

      UniProtKB/TrEMBL
      B5BU82

    8. XM_054373715.1 → XP_054229690.1  suppressor of cytokine signaling 2 isoform X3

      UniProtKB/TrEMBL
      B5BU82

    9. XM_054373714.1 → XP_054229689.1  suppressor of cytokine signaling 2 isoform X2

      UniProtKB/TrEMBL
      B5BU82

    10. XM_054373708.1 → XP_054229683.1  suppressor of cytokine signaling 2 isoform X1

      UniProtKB/TrEMBL
      B5BU82

    RNA

    1. XR_008488706.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14508.1 GenPept UniProtKB/Swiss-Prot:O14508

    Gene LinkOut

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