ZNF471 zinc finger protein 471 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF471provided by HGNC
Official Full Name: zinc finger protein 471provided by HGNC
Primary source: HGNC:HGNC:23226
See related: Ensembl:ENSG00000196263 MIM:620162; AllianceGenome:HGNC:23226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ERP1; Z1971; Zfp78
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary (RPKM 3.7), endometrium (RPKM 2.7) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (56507855..56530212)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (59602138..59624646)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (57019224..57041581)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc.
Title: Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc.
ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma.
Title: ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma.
The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/beta-catenin signaling.
Title: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling.
ZNF471 acts as a tumor suppressor in gastric cancer by transcriptionally inhibiting downstream targets TFAP2A and PLS3.
Title: Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A.
This is the first study to report hypermethylation of LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue
Title: Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G59638 (e-PCR)
- UniSTS:136794

D19S210 (e-PCR)
- UniSTS:14188

D19S210 (e-PCR)
- UniSTS:64413

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: zinc finger protein 471

Names: EZFIT-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001321768.2 → NP_001308697.1 zinc finger protein 471 isoform 2

Status: VALIDATED

Source sequence(s)

AC004696, AC005498, AI375847, AL831845, BM991696

UniProtKB/Swiss-Prot

Q9BX82

Conserved Domains (3) summary

COG5048
Location:129 → 536

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:443 → 463

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:483 → 507

zf-H2C2_2; Zinc-finger double domain
NM_020813.4 → NP_065864.2 zinc finger protein 471 isoform 1

See identical proteins and their annotated locations for NP_065864.2

Status: VALIDATED

Source sequence(s)

AC005498, AI375847, AL831845, BC125221, BM991696

Consensus CDS

CCDS12945.1

UniProtKB/Swiss-Prot

B4DF32, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1

Related

ENSP00000309161.4, ENST00000308031.10

Conserved Domains (5) summary

smart00349
Location:14 → 73

KRAB; krueppel associated box

COG5048
Location:203 → 610

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:517 → 537

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:14 → 53

KRAB; KRAB box

pfam13465
Location:557 → 581

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

56507855..56530212

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011527148.2 → XP_011525450.1 zinc finger protein 471 isoform X1

See identical proteins and their annotated locations for XP_011525450.1

UniProtKB/Swiss-Prot

B4DF32, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1

Conserved Domains (5) summary

smart00349
Location:14 → 73

KRAB; krueppel associated box

COG5048
Location:203 → 610

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:517 → 537

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:14 → 53

KRAB; KRAB box

pfam13465
Location:557 → 581

zf-H2C2_2; Zinc-finger double domain
XM_047439129.1 → XP_047295085.1 zinc finger protein 471 isoform X1

UniProtKB/Swiss-Prot

B4DF32, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1
XM_047439128.1 → XP_047295084.1 zinc finger protein 471 isoform X1

UniProtKB/Swiss-Prot

B4DF32, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1