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    HAND2-AS1 HAND2 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 79804, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HAND2-AS1provided by HGNC
    Official Full Name
    HAND2 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:48872
    See related
    Ensembl:ENSG00000237125 MIM:617240; AllianceGenome:HGNC:48872
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UPH; DEIN; NBLA00301
    Summary
    Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Predicted to act upstream of or within transcription elongation by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in endometrium (RPKM 13.8), adrenal (RPKM 11.4) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HAND2-AS1 in Genome Data Viewer
    Location:
    4q34.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (173528600..173591255)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (176868392..176930983)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174449751..174512406)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stimulator of chondrogenesis 1 Neighboring gene uncharacterized LOC101928409 Neighboring gene uncharacterized LOC124900815 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:174439311-174440510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:174445895-174446436 Neighboring gene uncharacterized LOC124900816 Neighboring gene NANOG hESC enhancer GRCh37_chr4:174457885-174458386 Neighboring gene heart and neural crest derivatives expressed 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:174529467-174530044 Neighboring gene mortality factor 4 (pseudogene) Neighboring gene RAN pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. HAND2-AS1 associates with outcomes of acute coronary syndrome and regulates cell viability of vascular endothelial cells. Wang J, et al. Ir J Med Sci, 2024 Feb. PMID 37464074
    2. Identification of DEIN, a novel gene with high expression levels in stage IVS neuroblastoma. Voth H, et al. Mol Cancer Res, 2007 Dec. PMID 18171985
    3. HAND2-AS1 rs2276941 Polymorphism Affecting the Binding of hsa-miR-1275 Is Associated with the Risk of Colorectal Cancer. Gao X, et al. DNA Cell Biol, 2022 Jun. PMID 35575749
    4. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. Wang Y, et al. EMBO J, 2019 Sep 2. PMID 31334575, Free PMC Article
    5. Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis. Bi HQ, et al. Hepatobiliary Pancreat Dis Int, 2020 Dec. PMID 32224127

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA HAND2-AS1 Suppresses Cell Proliferation, Migration, and Invasion of Bladder Cancer via miR-17-5p/KLF9 Axis.
      Title: Long Noncoding RNA HAND2-AS1 Suppresses Cell Proliferation, Migration, and Invasion of Bladder Cancer via miR-17-5p/KLF9 Axis.
    2. Activation of HAND2-FGFR signaling pathway by lncRNA HAND2-AS1 in adenomyosisdagger.
      Title: Activation of HAND2-FGFR signaling pathway by lncRNA HAND2-AS1 in adenomyosis†.
    3. HAND2-AS1 associates with outcomes of acute coronary syndrome and regulates cell viability of vascular endothelial cells.
      Title: HAND2-AS1 associates with outcomes of acute coronary syndrome and regulates cell viability of vascular endothelial cells.
    4. Bladder Cancer Progression Is Suppressed Through the Heart and Neural Crest Derivatives Expressed 2-Antisense RNA 1/microRNA-93-5p/Defective in Cullin Neddylation 1 Domain Containing 3 Axis.
      Title: Bladder Cancer Progression Is Suppressed Through the Heart and Neural Crest Derivatives Expressed 2-Antisense RNA 1/microRNA-93-5p/Defective in Cullin Neddylation 1 Domain Containing 3 Axis.
    5. LncRNA HAND2-AS1 attenuates glioma cell proliferation, invasion and migration by targeting CDK6.
      Title: LncRNA HAND2-AS1 attenuates glioma cell proliferation, invasion and migration by targeting CDK6.
    6. HAND2-AS1 rs2276941 Polymorphism Affecting the Binding of hsa-miR-1275 Is Associated with the Risk of Colorectal Cancer.
      Title: HAND2-AS1 rs2276941 Polymorphism Affecting the Binding of hsa-miR-1275 Is Associated with the Risk of Colorectal Cancer.
    7. Construction and Analysis of lncRNA-Associated ceRNA Network in Atherosclerotic Plaque Formation.
      Title: Construction and Analysis of lncRNA-Associated ceRNA Network in Atherosclerotic Plaque Formation.
    8. Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis.
      Title: Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis.
    9. HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis.
      Title: HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis.
    10. Long noncoding RNA HAND2AS1/miR106a/PTEN axis resensitizes cisplatinresistant ovarian cells to cisplatin treatment.
      Title: Long non‑coding RNA HAND2‑AS1/miR‑106a/PTEN axis re‑sensitizes cisplatin‑resistant ovarian cells to cisplatin treatment.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • HAND2 antisense RNA 1 (head to head)
    • differentially expressed in neuroblastoma
    • neuroblastoma transcript 301

    Clone Names

    • FLJ11539, FLJ41674, FLJ50876

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003679.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1)
      Source sequence(s)
      AA156933, EF529505
      Related
      ENST00000505621.6

    2. NR_136192.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2)
      Source sequence(s)
      AA156933, BQ882603, EU000853
      Related
      ENST00000507062.7

    3. NR_136193.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3)
      Source sequence(s)
      AA156933, AB075501, AC093849, BQ882603, EU000853

    4. NR_136194.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4)
      Source sequence(s)
      AA156933, AK300846, BQ882603, EU000853

    5. NR_136195.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5)
      Source sequence(s)
      AC093849, AC113154, AK054605, BQ882603
      Related
      ENST00000503474.5

    6. NR_136196.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6)
      Source sequence(s)
      AC079789, BQ882603, DA863153, DB292439

    7. NR_136197.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7)
      Source sequence(s)
      AA156933, DC421261, EU000853

    8. NR_136198.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8)
      Source sequence(s)
      AA156933, BG519698, BQ882603, EU000853

    9. NR_136199.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9)
      Source sequence(s)
      AA156933, AC093849, BQ882603, DC386781, EU000853

    10. NR_136200.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10)
      Source sequence(s)
      AA156933, AB075501, AU253586, BQ882603, EU000853
      Related
      ENST00000502896.6

    11. NR_136201.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11)
      Source sequence(s)
      AA156933, AB075501, AC093849, BQ882603, DA665500, EU000853

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      173528600..173591255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      176868392..176930983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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