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    CDCA5 cell division cycle associated 5 [ Homo sapiens (human) ]

    Gene ID: 113130, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CDCA5provided by HGNC
    Official Full Name
    cell division cycle associated 5provided by HGNC
    Primary source
    HGNC:HGNC:14626
    See related
    Ensembl:ENSG00000146670 MIM:609374; AllianceGenome:HGNC:14626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SORORIN
    Summary
    Predicted to enable chromatin binding activity. Involved in chromosome organization; double-strand break repair; and positive regulation of exit from mitosis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bone marrow (RPKM 12.1), testis (RPKM 11.0) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDCA5 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65061093..65084040, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65054375..65077318, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64844925..64851512, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene Sharpr-MPRA regulatory region 4003 Neighboring gene sorting nexin 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64811302-64811848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64814570-64815448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64815449-64816327 Neighboring gene SAC3 domain containing 1 Neighboring gene N-acetylated alpha-linked acidic dipeptidase like 1 Neighboring gene Sharpr-MPRA regulatory region 288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64846103-64846604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64852413-64852997 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64857368-64857540 Neighboring gene zinc finger protein like 1 Neighboring gene transmembrane protein 262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64863491-64864285 Neighboring gene Sharpr-MPRA regulatory region 6888 Neighboring gene VPS51 subunit of GARP complex Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64877599-64878526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64878527-64879452

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells. Zhang Q, et al. J Ovarian Res, 2024 Mar 27. PMID 38539247, Free PMC Article
    2. Regulation of centromeric cohesion by sororin independently of the APC/C. Díaz-Martínez LA, et al. Cell Cycle, 2007 Mar 15. PMID 17361102
    3. Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Nguyen MH, et al. Cancer Res, 2010 Jul 1. PMID 20551060
    4. A conserved motif at the C terminus of sororin is required for sister chromatid cohesion. Wu FM, et al. J Biol Chem, 2011 Feb 4. PMID 21115494, Free PMC Article
    5. C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion. Zhang N, et al. Cell Cycle, 2015. PMID 25608232, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1.
      Title: CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1.
    2. CDCA5 promoted cell invasion and migration by activating TGF-beta1 pathway in human ovarian cancer cells.
      Title: CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells.
    3. KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.
      Title: KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.
    4. CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.
      Title: CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.
    5. Loss of cell division cycleassociated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
      Title: Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
    6. Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
      Title: Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
    7. Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.
      Title: Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.
    8. TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
      Title: TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
    9. CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.
      Title: CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.
    10. LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.
      Title: LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC16386

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome TAS
    Traceable Author Statement
    more info
    		  
    located_in chromosome, centromeric region TAS
    Traceable Author Statement
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sororin
    Names
    cell division cycle-associated protein 5
    p35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433518.1 → NP_001420447.1  sororin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP003068

    2. NM_080668.4 → NP_542399.1  sororin isoform 1

      See identical proteins and their annotated locations for NP_542399.1

      Status: VALIDATED

      Source sequence(s)
      AP003068, BC011000
      Consensus CDS
      CCDS8091.1
      UniProtKB/Swiss-Prot
      A8K625, Q96FF9
      UniProtKB/TrEMBL
      B5MBX0
      Related
      ENSP00000275517.3, ENST00000275517.8
      Conserved Domains (1) summary
      pfam09666
      Location:89 → 209
      Sororin; Sororin protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65061093..65084040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544743.4 → XP_011543045.1  sororin isoform X3

      Conserved Domains (1) summary
      pfam09666
      Location:89 → 209
      Sororin; Sororin protein

    2. XM_017017158.3 → XP_016872647.1  sororin isoform X4

    3. XM_011544747.4 → XP_011543049.1  sororin isoform X5

    4. XM_005273734.5 → XP_005273791.1  sororin isoform X2

      Conserved Domains (1) summary
      pfam09666
      Location:89 → 209
      Sororin; Sororin protein

    5. XM_005273733.5 → XP_005273790.1  sororin isoform X1

      Conserved Domains (1) summary
      pfam09666
      Location:89 → 209
      Sororin; Sororin protein

    6. XM_011544749.4 → XP_011543051.1  sororin isoform X7

      Conserved Domains (1) summary
      pfam09666
      Location:89 → 209
      Sororin; Sororin protein

    7. XM_011544748.4 → XP_011543050.1  sororin isoform X6

      Conserved Domains (1) summary
      pfam09666
      Location:89 → 209
      Sororin; Sororin protein

    RNA

    1. XR_001747758.3 RNA Sequence

    2. XR_001747757.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65054375..65077318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367586.1 → XP_054223561.1  sororin isoform X3

    2. XM_054367587.1 → XP_054223562.1  sororin isoform X4

    3. XM_054367588.1 → XP_054223563.1  sororin isoform X5

    4. XM_054367584.1 → XP_054223559.1  sororin isoform X1

    5. XM_054367585.1 → XP_054223560.1  sororin isoform X2

    6. XM_054367590.1 → XP_054223565.1  sororin isoform X7

    7. XM_054367589.1 → XP_054223564.1  sororin isoform X6

    RNA

    1. XR_008488337.1 RNA Sequence

    2. XR_008488336.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96FF9.1 GenPept UniProtKB/Swiss-Prot:Q96FF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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