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    LZIC leucine zipper and CTNNBIP1 domain containing [ Homo sapiens (human) ]

    Gene ID: 84328, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LZICprovided by HGNC
    Official Full Name
    leucine zipper and CTNNBIP1 domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:17497
    See related
    Ensembl:ENSG00000162441 MIM:610458; AllianceGenome:HGNC:17497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable beta-catenin binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 8.7), colon (RPKM 7.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LZIC in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9922118..9943391, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9465032..9486296, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9982176..10003449, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9911316-9912116 Neighboring gene catenin beta interacting protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9919701-9920595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9931412-9932340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9932341-9933268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 236 Neighboring gene uncharacterized LOC124903838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9943986-9944775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9946851-9947439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9960261-9960762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9970922-9971595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9971596-9972268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9987872-9988381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9990871-9991370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9998882-9999382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9999383-9999883 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:10002582-10003781 Neighboring gene RN7SK pseudogene 269 Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene transmembrane protein 274, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain. Katoh M. Int J Mol Med, 2001 Dec. PMID 11712074
    2. Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation. Skalka G, et al. Cell Cycle, 2019 May. PMID 30973299, Free PMC Article
    3. Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy. Claudio JO, et al. Genomics, 1998 May 15. PMID 9628821
    4. Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Arumughan A, et al. Nat Commun, 2016 Oct 20. PMID 27762274, Free PMC Article
    5. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LZIC is functionally involved in cellular response to ionizing radiation, and its expression level could serve as a biomarker for patient stratification in clinical cancer practice.
      Title: Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC15436

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein LZIC
    Names
    leucine zipper and CTNNBIP1 domain-containing protein
    leucine zipper and ICAT homologous domain-containing protein
    leucine zipper domain and ICAT homologous domain containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316973.2 → NP_001303902.1  protein LZIC isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK312550, AL357140, CB241987, DA538145
      Consensus CDS
      CCDS107.1
      UniProtKB/Swiss-Prot
      B2R6F0, B4E2N0, Q8WZA0, Q96IU1
      Related
      ENSP00000366418.1, ENST00000377213.1
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 188
      ICAT; Beta-catenin-interacting protein ICAT

    2. NM_001316974.2 → NP_001303903.1  protein LZIC isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice junctions in the 5' end compared to variant 1. The resulting isoform (b) is longer at the N-terminus compared to isoform a.
      Source sequence(s)
      AK304348, AL357140, CB241987, DA538145
      UniProtKB/Swiss-Prot
      Q8WZA0
      Conserved Domains (1) summary
      pfam06384
      Location:134 → 209
      ICAT; Beta-catenin-interacting protein ICAT

    3. NM_001316975.2 → NP_001303904.1  protein LZIC isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate terminal exon compared to variant 1. The resulting isoform (c) has a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BI772110, BQ018333, DA538145
      UniProtKB/TrEMBL
      K7ES95
      Related
      ENSP00000468610.1, ENST00000488540.5
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 172
      ICAT; Beta-catenin-interacting protein ICAT

    4. NM_001316976.2 → NP_001303905.1  protein LZIC isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks two alternate coding exons compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL357140, CB241987, DA538145, DB106543
      Conserved Domains (1) summary
      pfam04111
      Location:8 → 87
      APG6; Autophagy protein Apg6

    5. NM_032368.5 → NP_115744.2  protein LZIC isoform a

      See identical proteins and their annotated locations for NP_115744.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AA220235, AL357140, BC007240, CB241987
      Consensus CDS
      CCDS107.1
      UniProtKB/Swiss-Prot
      B2R6F0, B4E2N0, Q8WZA0, Q96IU1
      Related
      ENSP00000366430.1, ENST00000377223.6
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 188
      ICAT; Beta-catenin-interacting protein ICAT

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      9922118..9943391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263506.3 → XP_005263563.1  protein LZIC isoform X1

      See identical proteins and their annotated locations for XP_005263563.1

      UniProtKB/TrEMBL
      K7ES95
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 172
      ICAT; Beta-catenin-interacting protein ICAT

    2. XM_017002546.2 → XP_016858035.1  protein LZIC isoform X2

      Conserved Domains (2) summary
      pfam06384
      Location:113 → 171
      ICAT; Beta-catenin-interacting protein ICAT
      pfam04111
      Location:8 → 87
      APG6; Autophagy protein Apg6

    3. XM_017002547.2 → XP_016858036.1  protein LZIC isoform X2

      Conserved Domains (2) summary
      pfam06384
      Location:113 → 171
      ICAT; Beta-catenin-interacting protein ICAT
      pfam04111
      Location:8 → 87
      APG6; Autophagy protein Apg6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      9465032..9486296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339191.1 → XP_054195166.1  protein LZIC isoform X1

      UniProtKB/TrEMBL
      K7ES95

    2. XM_054339193.1 → XP_054195168.1  protein LZIC isoform X2

    3. XM_054339192.1 → XP_054195167.1  protein LZIC isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WZA0.1 GenPept UniProtKB/Swiss-Prot:Q8WZA0

    Gene LinkOut

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