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    IRC19 Irc19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850626, updated on 17-Dec-2024

    Summary

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    Official Symbol
    IRC19
    Official Full Name
    Irc19p
    Primary source
    SGD:S000003956
    Locus tag
    YLL033W
    See related
    AllianceGenome:SGD:S000003956; FungiDB:YLL033W; VEuPathDB:YLL033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RRG4
    Summary
    Involved in ascospore formation and mitotic recombination. Acts upstream of or within double-strand break repair. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IRC19 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (73409..74101)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene polynucleotide 5'-hydroxyl-kinase Neighboring gene putative AAA family ATPase RIX7 Neighboring gene uncharacterized protein Neighboring gene mannose-ethanolamine phosphotransferase GPI13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of IRC19 Causes Defects in DNA Double-Strand Break Repair Pathways in Saccharomyces cerevisiae. Choi JH, et al. J Microbiol, 2024 Sep. PMID 38995433
    2. Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae. Deutschbauer AM, et al. Proc Natl Acad Sci U S A, 2002 Nov 26. PMID 12432101, Free PMC Article
    3. Disruption of six novel ORFs on the left arm of chromosome XII reveals one gene essential for vegetative growth of Saccharomyces cerevisiae. Zhang N, et al. Yeast, 1999 Sep 15. PMID 10487931
    4. Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid. Muñoz-Galván S, et al. PLoS Genet, 2013. PMID 23357952, Free PMC Article
    5. Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning. Peng Y, et al. Mol Biol Cell, 2015 Jul 1. PMID 25971801, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Irc19p
    NP_013067.1
    • Protein involved in DNA double-strand break repair; synergistic defect in DSB repair via single-strand annealing with the RAD52 null mutant; possible role in the end resection process; non-essential gene; null mutant has a sporulation defect, displays increased levels of spontaneous Rad52p foci and has a respiratory growth defect

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      73409..74101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181853.1 → NP_013067.1  TPA: Irc19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A0M4, C7GQE4, D6VXX2, Q07843
      UniProtKB/TrEMBL
      G2WIG3, N1NZV0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07843.1

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