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    Plxdc2 plexin domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 67448, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Plxdc2provided by MGI
    Official Full Name
    plexin domain containing 2provided by MGI
    Primary source
    MGI:MGI:1914698
    See related
    Ensembl:ENSMUSG00000026748 AllianceGenome:MGI:1914698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tem7r; 1200007L24Rik; 5430431D22Rik
    Summary
    Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; inner ear; limb; skin; and trunk mesenchyme. Orthologous to human PLXDC2 (plexin domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 9.4), lung adult (RPKM 7.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plxdc2 in Genome Data Viewer
    Location:
    2 A2- A3; 2 11.8 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (16360551..16765941)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (16355740..16761132)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene MAM and LDL receptor class A domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_03749 Neighboring gene STARR-seq mESC enhancer starr_03750 Neighboring gene Hmgb1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03751 Neighboring gene STARR-seq mESC enhancer starr_03754 Neighboring gene STARR-seq mESC enhancer starr_03755 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_03757 Neighboring gene STARR-seq mESC enhancer starr_03758 Neighboring gene STARR-seq mESC enhancer starr_03759 Neighboring gene RIKEN cDNA 4930515L03 gene Neighboring gene STARR-seq mESC enhancer starr_03760 Neighboring gene STARR-seq mESC enhancer starr_03761 Neighboring gene STARR-seq mESC enhancer starr_03762 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_03764 Neighboring gene predicted gene, 54103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of new regulatory genes through expression pattern analysis of a global RNA-seq dataset from a Helicobacter pylori co-culture system. Tubau-Juni N, et al. Sci Rep, 2020 Jul 13. PMID 32661418, Free PMC Article
    2. Plxdc2 is a mitogen for neural progenitors. Miller-Delaney SF, et al. PLoS One, 2011 Jan 21. PMID 21283688, Free PMC Article
    3. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Nanda A, et al. Cancer Res, 2004 Dec 1. PMID 15574754
    4. Expression of Plxdc2/TEM7R in the developing nervous system of the mouse. Miller SF, et al. Gene Expr Patterns, 2007 Apr. PMID 17280871
    5. Cell surface tumor endothelial markers are conserved in mice and humans. Carson-Walter EB, et al. Cancer Res, 2001 Sep 15. PMID 11559528

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of new regulatory genes through expression pattern analysis of a global RNA-seq dataset from a Helicobacter pylori co-culture system.
      Title: Identification of new regulatory genes through expression pattern analysis of a global RNA-seq dataset from a Helicobacter pylori co-culture system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plexin domain-containing protein 2
    Names
    tumor endothelial marker 7 related
    tumor endothelial marker 7-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026162.6 → NP_080438.2  plexin domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_080438.2

      Status: VALIDATED

      Source sequence(s)
      AK035165, AL928882, AW045408
      Consensus CDS
      CCDS15705.1
      UniProtKB/Swiss-Prot
      Q6PET5, Q91ZV6, Q9DC11
      UniProtKB/TrEMBL
      B1AY86
      Related
      ENSMUSP00000028081.7, ENSMUST00000028081.13
      Conserved Domains (2) summary
      pfam01437
      Location:327 → 372
      PSI; Plexin repeat
      cl02648
      Location:191 → 282
      NIDO; Nidogen-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      16360551..16765941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497531.4 → XP_006497594.1  plexin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B1AY85, B1AY86
      Related
      ENSMUSP00000110350.2, ENSMUST00000114702.2
      Conserved Domains (2) summary
      pfam01437
      Location:327 → 372
      PSI; Plexin repeat
      cl02648
      Location:191 → 282
      NIDO; Nidogen-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC11.1 GenPept UniProtKB/Swiss-Prot:Q9DC11

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools