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    Ppig peptidyl-prolyl isomerase G (cyclophilin G) [ Mus musculus (house mouse) ]

    Gene ID: 228005, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppigprovided by MGI
    Official Full Name
    peptidyl-prolyl isomerase G (cyclophilin G)provided by MGI
    Primary source
    MGI:MGI:2445173
    See related
    Ensembl:ENSMUSG00000042133 AllianceGenome:MGI:2445173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CYP; SRCyp; B230312B02Rik
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be located in cytosol; nuclear matrix; and nuclear speck. Predicted to be active in mitochondrion and nucleus. Orthologous to human PPIG (peptidylprolyl isomerase G). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 10.4), CNS E14 (RPKM 6.5) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppig in Genome Data Viewer
    Location:
    2 C2; 2 40.95 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69553152..69584356)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69722753..69754059)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kelch-like 41 Neighboring gene FAST kinase domains 1 Neighboring gene STARR-seq mESC enhancer starr_04743 Neighboring gene STARR-positive B cell enhancer ABC_E10110 Neighboring gene STARR-positive B cell enhancer mm9_chr2:69582878-69583179 Neighboring gene 60S ribosomal protein L13-like Neighboring gene cilia and flagella associated protein 210 Neighboring gene STARR-seq mESC enhancer starr_04744 Neighboring gene STARR-positive B cell enhancer ABC_E4461 Neighboring gene phosphatase, orphan 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
    2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    3. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
    4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase G
    Names
    PPIase G
    cyclophilin G
    peptidylprolyl isomerase G
    rotamase G
    NP_001074555.1
    NP_001394390.1
    NP_001394391.1
    NP_001394392.1
    NP_001394393.1
    NP_001394394.1
    NP_001394395.1
    NP_001394397.1
    NP_001394402.1
    NP_001394403.1
    NP_001394404.1
    NP_001394405.1
    NP_001394406.1
    NP_001394407.1
    NP_001394408.1
    NP_001394409.1
    NP_001394410.1
    NP_001394411.1
    NP_001394412.1
    NP_001394413.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081086.2 → NP_001074555.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      See identical proteins and their annotated locations for NP_001074555.1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      Consensus CDS
      CCDS38137.1
      UniProtKB/Swiss-Prot
      A2AR02, O70134, Q3TP68, Q3UXE0
      UniProtKB/TrEMBL
      B2RWT5
      Related
      ENSMUSP00000045945.9, ENSMUST00000040915.15
      Conserved Domains (2) summary
      PTZ00121
      Location:401 → 750
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8 → 175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    2. NM_001407461.1 → NP_001394390.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      A2AR02, O70134, Q3TP68, Q3UXE0

    3. NM_001407462.1 → NP_001394391.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      A2AR02, O70134, Q3TP68, Q3UXE0

    4. NM_001407463.1 → NP_001394392.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      A2AR02, O70134, Q3TP68, Q3UXE0
      Related
      ENSMUSP00000088370.4, ENSMUST00000090858.10

    5. NM_001407464.1 → NP_001394393.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      A2AR02, O70134, Q3TP68, Q3UXE0

    6. NM_001407465.1 → NP_001394394.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      A2AR02, O70134, Q3TP68, Q3UXE0

    7. NM_001407466.1 → NP_001394395.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      A2AR02, O70134, Q3TP68, Q3UXE0

    8. NM_001407468.1 → NP_001394397.1  peptidyl-prolyl cis-trans isomerase G isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845261

    9. NM_001407473.1 → NP_001394402.1  peptidyl-prolyl cis-trans isomerase G isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845261

    10. NM_001407474.1 → NP_001394403.1  peptidyl-prolyl cis-trans isomerase G isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845261

    11. NM_001407475.1 → NP_001394404.1  peptidyl-prolyl cis-trans isomerase G isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845261

    12. NM_001407476.1 → NP_001394405.1  peptidyl-prolyl cis-trans isomerase G isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL845261

    13. NM_001407477.1 → NP_001394406.1  peptidyl-prolyl cis-trans isomerase G isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL845261

    14. NM_001407478.1 → NP_001394407.1  peptidyl-prolyl cis-trans isomerase G isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL845261

    15. NM_001407479.1 → NP_001394408.1  peptidyl-prolyl cis-trans isomerase G isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL845261

    16. NM_001407480.1 → NP_001394409.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261

    17. NM_001407481.1 → NP_001394410.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261

    18. NM_001407482.1 → NP_001394411.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261

    19. NM_001407483.1 → NP_001394412.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261

    20. NM_001407484.1 → NP_001394413.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261

    RNA

    1. NR_176367.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845261

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69553152..69584356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AR02.1 GenPept UniProtKB/Swiss-Prot:A2AR02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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