MAL11 alpha-glucoside permease [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MAL11
Official Full Name: alpha-glucoside permease
Primary source: SGD:S000003521
Locus tag: YGR289C
See related: AllianceGenome:SGD:S000003521; FungiDB:YGR289C; VEuPathDB:YGR289C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AGT1
Summary: Enables alpha-glucoside:proton symporter activity; maltose:proton symporter activity; and trehalose transmembrane transporter activity. Involved in disaccharide catabolic process; maltose transport; and trehalose transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MAL11 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (1073963..1075813, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The lack of trehalose transporter Agt1 in Saccharomyces cerevisiae reduces cell tolerance to 51 degrees C and increases lipid peroxidation. The damage is reversed when external trehalose is added during 40 degrees C adaptation, confirming that the reason for the agt1Delta sensitivity is the absence of trehalose at the outside of the lipid bilayer. Agt1 is found into vesicles near to plasma membrane in response to stress.
Title: The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.
Identification of amino acid residues of the AGT1 permease, that are required for the active transport of sugars.
Title: Key amino acid residues of the AGT1 permease required for maltotriose consumption and fermentation by Saccharomyces cerevisiae.
The study indicates that functionality of alpha-glucoside transporter Agt1 depends on water in S. cerevisiae strain 14 but not in S. cerevisiae strain 77.
Title: Activity of the α-glucoside transporter Agt1 in Saccharomyces cerevisiae cells during dehydration-rehydration events.
AGT1 has a role in trehalose import into the Saccharomyces cerevisiae cell
Title: Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter.
The behaviour of the triple Deltanth1Deltanth2Deltaath1 and quadruple Deltanth1Deltanth2Deltaath1Deltaagt1 mutant strains rules out the participation of the Agt1p in the mobilization of intracellular trehalose during growth recovery after saline stress.
Title: The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.
The AGT1 transporter is required for efficient maltotriose fermentation by S. cerevisiae yeasts, highlighting the importance of this permease for breeding and/or selection programs aimed at improving sluggish maltotriose fermentations.
Title: Molecular analysis of maltotriose active transport and fermentation by Saccharomyces cerevisiae reveals a determinant role for the AGT1 permease.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha-glucoside:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables maltose:proton symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables trehalose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in disaccharide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maltose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in maltose transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maltose transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in trehalose transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-glucoside permease

NP_011805.3

High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

1073963..1075813 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181418.3 → NP_011805.3 TPA: alpha-glucoside permease [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011805.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV66, N1PA11, P53048

UniProtKB/TrEMBL

B0M8V7, F8LG02

Conserved Domains (1) summary

TIGR00879
Location:81 → 563

SP; MFS transporter, sugar porter (SP) family