Fstl1 follistatin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fstl1provided by MGI
Official Full Name: follistatin-like 1provided by MGI
Primary source: MGI:MGI:102793
See related: Ensembl:ENSMUSG00000022816 AllianceGenome:MGI:102793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fstl; TSC-36
Summary: Predicted to enable calcium ion binding activity and heparin binding activity. Involved in endothelial cell differentiation; endothelial cell migration; and negative regulation of apoptotic process. Acts upstream of or within hematopoietic stem cell homeostasis. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; limb; and sensory organ. Used to study pulmonary emphysema. Orthologous to human FSTL1 (follistatin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 177.9), bladder adult (RPKM 102.9) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 26.48 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (37597417..37656878)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (37777055..37836516)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway.
Title: Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway.
Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1.
Title: Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1.
Single-cell transcriptome analysis reveals cellular heterogeneity and highlights Fstl1-regulated alveolar myofibroblasts in mouse lung at birth.
Title: Single-cell transcriptome analysis reveals cellular heterogeneity and highlights Fstl1-regulated alveolar myofibroblasts in mouse lung at birth.
FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
Title: FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
miR-125a-3p regulates the expression of FSTL1, a pro-inflammatory factor, during adipogenic differentiation, and inhibits adipogenesis in mice.
Title: miR-125a-3p regulates the expression of FSTL1, a pro-inflammatory factor, during adipogenic differentiation, and inhibits adipogenesis in mice.
Follistatin-like 1 mitigates intermittent hypoxia-induced melanoma lung metastasis in mice.
Title: Follistatin-like 1 mitigates intermittent hypoxia-induced melanoma lung metastasis in mice.
FSTL1-knockdown improves neural oscillation via decreasing neuronal-inflammation regulating apoptosis in Abeta1-42 induced AD model mice.
Title: FSTL1-knockdown improves neural oscillation via decreasing neuronal-inflammation regulating apoptosis in Aβ(1-42) induced AD model mice.
FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2.
Title: FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2.
Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/beta-catenin signaling in obstructed kidneys in vivo.
Title: Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo.
Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-kappaB pathway in CUMS mice.
Title: Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-κB pathway in CUMS mice.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (2)
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fstl1 (e-PCR), detects polymorphism
- UniSTS:472853

Fstl (e-PCR), detects polymorphism
- UniSTS:143145

24.MMHAP33FLH3.seq (e-PCR)
- UniSTS:160569

AW107808 (e-PCR)
- UniSTS:180907

RH136117 (e-PCR)
- UniSTS:210112

Fstl1 (e-PCR), detects polymorphism
- UniSTS:532173

NoName (e-PCR)
- UniSTS:224760

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	HDA more info	PubMed

General protein information

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Preferred Names: follistatin-related protein 1

Names: TGF-beta-inducible protein TSC-36; follistatin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008047.5 → NP_032073.2 follistatin-related protein 1 precursor

See identical proteins and their annotated locations for NP_032073.2

Status: PROVISIONAL

Source sequence(s)

AC129539

Consensus CDS

CCDS37339.1

UniProtKB/Swiss-Prot

Q62356, Q6GTX2, Q99JI9

Related

ENSMUSP00000110411.3, ENSMUST00000114763.3

Conserved Domains (5) summary

smart00274
Location:29 → 51

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:52 → 96

KAZAL; Kazal type serine protease inhibitors

pfam13499
Location:147 → 218

EF-hand_7; EF-hand domain pair

cl08302
Location:147 → 218

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl17735
Location:231 → 278

VWC; von Willebrand factor type C domain