Myh11 myosin, heavy polypeptide 11, smooth muscle [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myh11provided by MGI
Official Full Name: myosin, heavy polypeptide 11, smooth muscleprovided by MGI
Primary source: MGI:MGI:102643
See related: Ensembl:ENSMUSG00000018830 AllianceGenome:MGI:102643
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SM1; SM2; smMHC
Summary: Enables cytoskeletal motor activity. Acts upstream of or within smooth muscle contraction. Located in brush border; smooth muscle contractile fiber; and stress fiber. Part of muscle myosin complex. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and vascular system. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome; patent ductus arteriosus; and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 911.5), colon adult (RPKM 71.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 9.71 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (14012392..14109227, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (14194527..14292188, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neonatal Streptococcus Pneumoniae pneumonia induces airway SMMHC expression through HMGB1/TLR4/ERK.
Title: Neonatal Streptococcus Pneumoniae pneumonia induces airway SMMHC expression through HMGB1/TLR4/ERK.
Novel Myh11 Dual Reporter Mouse Model Provides Definitive Labeling and Identification of Smooth Muscle Cells-Brief Report.
Title: Novel Myh11 Dual Reporter Mouse Model Provides Definitive Labeling and Identification of Smooth Muscle Cells-Brief Report.
LncRNA Sox2ot modulates the progression of thoracic aortic aneurysm by regulating miR-330-5p/Myh11.
Title: LncRNA Sox2ot modulates the progression of thoracic aortic aneurysm by regulating miR-330-5p/Myh11.
RUNX1 and CBFbeta-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development.
Title: RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development.
Gata2 deficiency delays leukemogenesis while contributing to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice.
Title: Gata2 deficiency delays leukemogenesis while contributing to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice.
altered thoracic ascending aorta (TAA) wall compliance of mutant Myh11 (R247C/+) mice had led to a higher TAA dilation degree than that in wildtypeand even could be the potential reason of TAA dissection and rupture
Title: [Pathophysiological Study on Thoracic Ascending Aorta of Mice with Myh11 (R247C) Heterozygous Mutation in Norepinephrine-induced Hypertension Model].
Results indicatethat the defect of smooth muscle myosin heavy chain (SM-MHC) lead to the bladder developing lesions initially at 15.5 dpc stage and also implied that the SM-MHC loss might result in the gas bubbles in stomach.
Title: Loss of smooth muscle myosin heavy chain results in the bladder and stomach developing lesion during foetal development in mice.
Force development responses were reduced in aortic tissue from a conditional knockout of smooth muscle myosin heavy chain in adult mice (Myh11+/- or Myh11-/-) with a greater reduction with homozygous vs heterozygous tissues. Similar reductions in force responses were obtained with tissues containing either a heterozygous or homozygous knockin mutation in smooth muscle myosin heavy chain (Myh11+/R247C or Myh11R247C/R247C).
Title: Genetic approaches to identify pathological limitations in aortic smooth muscle contraction.
Chd7 deficiency delays leukemia initiation induced by Cbfb-MYH11.
Title: Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11.
Cbfbeta-SMMHC and Nras(G12D) promote the survival of preleukemic myeloid progenitors primed for leukemia by activation of the MEK/ERK/Bim axis, and define Nras(LSL-G12D); Cbfb(56M) mice as a valuable genetic model for the study of AML therapies.
Title: NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (7) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myh11 (e-PCR), detects polymorphism
- UniSTS:143952

Myh11 (e-PCR), detects polymorphism
- UniSTS:143953

Myh11 (e-PCR), detects polymorphism
- UniSTS:143954

D85923 (e-PCR)
- UniSTS:180868

AV071570 (e-PCR)
- UniSTS:178841

NoName (e-PCR)
- UniSTS:548526

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in elastic fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in elastic fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle myosin thick filament assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
part_of muscle myosin complex	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in smooth muscle contractile fiber	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin-11

Names: myosin heavy chain 11, smooth muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161775.2 → NP_001155247.1 myosin-11 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a longer and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC164291

Consensus CDS

CCDS88881.1

UniProtKB/TrEMBL

E9QPE7, Q69ZX3

Related

ENSMUSP00000087756.5, ENSMUST00000090287.5

Conserved Domains (8) summary

cl14654
Location:1020 → 1292

V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains

cd14921
Location:99 → 771

MYSc_Myh11; class II myosin heavy chain 11, motor domain

pfam00063
Location:87 → 771

Myosin_head; Myosin head (motor domain)

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 71

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:990 → 1082

FAM76; FAM76 protein

cl23717
Location:1066 → 1124

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

cl24005
Location:1780 → 1867

DUF2570; Protein of unknown function (DUF2570)
NM_001402795.1 → NP_001389724.1 myosin-11 isoform 3

Status: VALIDATED

Source sequence(s)

AC164291

UniProtKB/TrEMBL

A0A338P6K2, Q69ZX3

Related

ENSMUSP00000156021.2, ENSMUST00000231567.2
NM_001402796.1 → NP_001389725.1 myosin-11 isoform 4

Status: VALIDATED

Source sequence(s)

AC164291

UniProtKB/TrEMBL

Q69ZX3
NM_013607.3 → NP_038635.2 myosin-11 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).

Source sequence(s)

AC164291

Consensus CDS

CCDS27972.1

UniProtKB/TrEMBL

A0A2R8VHF9, Q69ZX3

Related

ENSMUSP00000155052.2, ENSMUST00000230397.2

Conserved Domains (9) summary

cl14654
Location:1020 → 1292

V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains

cd14921
Location:99 → 771

MYSc_Myh11; class II myosin heavy chain 11, motor domain

pfam00063
Location:87 → 771

Myosin_head; Myosin head (motor domain)

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 71

Myosin_N; Myosin N-terminal SH3-like domain

pfam09798
Location:1819 → 1935

LCD1; DNA damage checkpoint protein

pfam16046
Location:990 → 1082

FAM76; FAM76 protein

cl23717
Location:1066 → 1124

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

cl24005
Location:1780 → 1867

DUF2570; Protein of unknown function (DUF2570)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

14012392..14109227 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521845.1 → XP_006521908.1 myosin-11 isoform X3

Conserved Domains (2) summary

cl22853
Location:1 → 31

Motor_domain; Myosin and Kinesin motor domain

pfam01576
Location:108 → 1188

Myosin_tail_1; Myosin tail