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    Zfp422 zinc finger protein 422 [ Mus musculus (house mouse) ]

    Gene ID: 67255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp422provided by MGI
    Official Full Name
    zinc finger protein 422provided by MGI
    Primary source
    MGI:MGI:1914505
    See related
    Ensembl:ENSMUSG00000059878 AllianceGenome:MGI:1914505
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KOX15; Znf22; Krox25; Krox26; Krox-26; Krox-25-2; 2900028O21Rik
    Summary
    This gene encodes a putative C2H2 zinc finger transcription factor that may play a role in tooth development. A pseudogene related to this gene is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Broad expression in CNS E11.5 (RPKM 40.6), CNS E14 (RPKM 29.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp422 in Genome Data Viewer
    Location:
    6 E3; 6 53.83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116600977..116605960, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116624016..116628999, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57758 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene Ras association (RalGDS/AF-6) domain family member 4 Neighboring gene STARR-seq mESC enhancer starr_17106 Neighboring gene microRNA 7043 Neighboring gene DEPP1 autophagy regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Krox-26 is a novel C2H2 zinc finger transcription factor expressed in developing dental and osteogenic tissues. Ganss B, et al. Connect Tissue Res, 2002. PMID 12489153
    2. Developmental expression pattern and DNA-binding properties of the zinc finger transcription factor Krox-26. Teo W, et al. Connect Tissue Res, 2003. PMID 12952191
    3. The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). Gao Y, et al. J Dent Res, 2003 Dec. PMID 14630903
    4. Tbx22 expressions during palatal development in fetuses with glucocorticoid-/alcohol-induced C57BL/6N cleft palates. Kim SM, et al. J Craniofac Surg, 2009 Sep. PMID 19816249
    5. Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis. Nie Y, et al. Cell Death Differ, 2020 May. PMID 31685980, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.
      Title: Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.
    2. human gene locus mapping assoicated with permanent tooth agenesis
      Title: The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency).
    3. analysis revealed an intense expression of Krox-25 mRNA in rat and mouse teeth; results suggest that Krox-25 plays an important role as a transcription factor for the cytodifferentiation and amelogenesis of enamel epithelium.
      Title: Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in odontogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 22
    Names
    Kruppel type zinc finger protein Krox26
    zinc finger protein Krox-25
    zinc finger protein Krox-26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302439.1 → NP_001289368.1  zinc finger protein 22

      See identical proteins and their annotated locations for NP_001289368.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK082970, AK152681, AK169251, BY074474
      Consensus CDS
      CCDS20459.1
      UniProtKB/Swiss-Prot
      Q3TF83, Q8VEK7, Q9ERU3
      UniProtKB/TrEMBL
      Q3U7F6
      Related
      ENSMUSP00000084926.3, ENSMUST00000057540.6
      Conserved Domains (2) summary
      COG5048
      Location:53 → 195
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001302440.1 → NP_001289369.1  zinc finger protein 22

      See identical proteins and their annotated locations for NP_001289369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK082970, AK152681, AK169251, BY059739
      Consensus CDS
      CCDS20459.1
      UniProtKB/Swiss-Prot
      Q3TF83, Q8VEK7, Q9ERU3
      UniProtKB/TrEMBL
      Q3U7F6
      Related
      ENSMUSP00000108501.2, ENSMUST00000112880.8
      Conserved Domains (2) summary
      COG5048
      Location:53 → 195
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_026057.3 → NP_080333.1  zinc finger protein 22

      See identical proteins and their annotated locations for NP_080333.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK082970, AK152681, AK169251, BY082381
      Consensus CDS
      CCDS20459.1
      UniProtKB/Swiss-Prot
      Q3TF83, Q8VEK7, Q9ERU3
      UniProtKB/TrEMBL
      Q3U7F6
      Related
      ENSMUSP00000078685.6, ENSMUST00000079749.6
      Conserved Domains (2) summary
      COG5048
      Location:53 → 195
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      116600977..116605960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255555.2 → XP_030111415.1  zinc finger protein 22 isoform X1

      UniProtKB/Swiss-Prot
      Q3TF83, Q8VEK7, Q9ERU3
      UniProtKB/TrEMBL
      Q3U7F6
      Conserved Domains (2) summary
      COG5048
      Location:53 → 195
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERU3.2 GenPept UniProtKB/Swiss-Prot:Q9ERU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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