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    Zng1 Zn regulated GTPase metalloprotein activator 1 [ Mus musculus (house mouse) ]

    Gene ID: 226043, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zng1provided by MGI
    Official Full Name
    Zn regulated GTPase metalloprotein activator 1provided by MGI
    Primary source
    MGI:MGI:2385089
    See related
    Ensembl:ENSMUSG00000024878 AllianceGenome:MGI:2385089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbwd1
    Summary
    Enables GTPase activity and zinc chaperone activity. Involved in intracellular zinc ion homeostasis; kidney development; and protein maturation. Located in nucleus. Is expressed in metanephros and vibrissa. Used to study CAKUT. Orthologous to several human genes including ZNG1A (Zn regulated GTPase metalloprotein activator 1A); ZNG1C (Zn regulated GTPase metalloprotein activator 1C); and ZNG1E (Zn regulated GTPase metalloprotein activator 1E). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 5.2), CNS E11.5 (RPKM 4.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zng1 in Genome Data Viewer
    Location:
    19 B; 19 19.86 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24897280..24939024, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24919629..24961663, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene forkhead box D4 Neighboring gene STARR-seq mESC enhancer starr_45808 Neighboring gene microRNA 3084-1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:25033055-25033356 Neighboring gene STARR-positive B cell enhancer ABC_E7639 Neighboring gene STARR-positive B cell enhancer ABC_E5693 Neighboring gene STARR-seq mESC enhancer starr_45809 Neighboring gene dedicator of cytokinesis 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:25126893-25127076 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4B Neighboring gene STARR-positive B cell enhancer ABC_E1974 Neighboring gene predicted gene, 34235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1 Gene Is associated with Congenital Anomalies of the Kidney and Urinary Tract. Kanda S, et al. J Am Soc Nephrol, 2020 Jan. PMID 31862704, Free PMC Article
    2. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Weiss A, et al. Cell, 2022 Jun 9. PMID 35584702, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28027, MGC59411

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc chaperone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular zinc ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc-regulated GTPase metalloprotein activator 1
    Names
    COBW domain containing 1
    COBW domain-containing protein 1
    cobalamin synthase W domain-containing protein 1
    cobalamin synthetase W domain-containing protein 1
    dopamine responsive protein
    NP_666209.1
    XP_030106750.1
    XP_030106751.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146097.3 → NP_666209.1  zinc-regulated GTPase metalloprotein activator 1

      See identical proteins and their annotated locations for NP_666209.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC123930, AC139711, AK132291
      Consensus CDS
      CCDS37942.1
      UniProtKB/Swiss-Prot
      Q7TSA8, Q8K399, Q8VEH6
      Related
      ENSMUSP00000025815.9, ENSMUST00000025815.10
      Conserved Domains (3) summary
      COG0523
      Location:40 → 376
      YejR; GTPase, G3E family [General function prediction only]
      pfam07683
      Location:271 → 374
      CobW_C; Cobalamin synthesis protein cobW C-terminal domain
      cl21455
      Location:41 → 205
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. NR_033744.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123930, AC139711

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      24897280..24939024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250890.2 → XP_030106750.1  zinc-regulated GTPase metalloprotein activator 1 isoform X1

      Conserved Domains (1) summary
      COG0523
      Location:1 → 180
      YejR; GTPase, G3E family [General function prediction only]

    2. XM_030250891.2 → XP_030106751.1  zinc-regulated GTPase metalloprotein activator 1 isoform X1

      Conserved Domains (1) summary
      COG0523
      Location:1 → 180
      YejR; GTPase, G3E family [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEH6.1 GenPept UniProtKB/Swiss-Prot:Q8VEH6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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