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    SEC53 phosphomannomutase SEC53 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC53
    Official Full Name
    phosphomannomutase SEC53
    Primary source
    SGD:S000001849
    Locus tag
    YFL045C
    See related
    AllianceGenome:SGD:S000001849; FungiDB:YFL045C; VEuPathDB:YFL045C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ALG4
    Summary
    Enables phosphomannomutase activity. Predicted to be involved in mannose metabolic process and protein N-linked glycosylation. Located in cytosol. Used to study congenital disorder of glycosylation Ia. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to human PMM1 (phosphomannomutase 1) and PMM2 (phosphomannomutase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC53 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (43628..44392, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein RGD2 Neighboring gene Fmp32p Neighboring gene ubiquitin-specific protease OTU1 Neighboring gene Lam5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Models of Phosphomannomutase 2 Deficiency, a Congenital Disorder of Glycosylation. Lao JP, et al. G3 (Bethesda), 2019 Feb 7. PMID 30530630, Free PMC Article
    2. The yeast SEC53 gene encodes phosphomannomutase. Kepes F, et al. J Biol Chem, 1988 Jul 5. PMID 3288631
    3. Product of SEC53 is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum. Feldman RI, et al. J Biol Chem, 1987 Jul 5. PMID 3298255
    4. Sec53, a protein required for an early step in secretory protein processing and transport in yeast, interacts with the cytoplasmic surface of the endoplasmic reticulum. Ruohola H, et al. Proc Natl Acad Sci U S A, 1987 Dec. PMID 3317409, Free PMC Article
    5. Characterization of a gene product (Sec53p) required for protein assembly in the yeast endoplasmic reticulum. Bernstein M, et al. J Cell Biol, 1985 Dec. PMID 3905826, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphomannomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphomannomutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphomannomutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mannose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphomannomutase SEC53
    NP_116609.1
    • Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; human homolog PMM2 complements yeast mutants

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      43628..44392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179922.1 → NP_116609.1  TPA: phosphomannomutase SEC53 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTI5, P07283, Q70D76, Q70D77
      UniProtKB/TrEMBL
      A7A1Z4, B3LUG6, B5VHY2, C7GY69, C8Z7N7, G2WD96, N1P4H2
      Conserved Domains (1) summary
      pfam03332
      Location:35 → 254
      PMM; Eukaryotic phosphomannomutase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07283.1

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