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    KAP123 karyopherin KAP123 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856846, updated on 17-Dec-2024

    Summary

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    Official Symbol
    KAP123
    Official Full Name
    karyopherin KAP123
    Primary source
    SGD:S000000912
    Locus tag
    YER110C
    See related
    AllianceGenome:SGD:S000000912; FungiDB:YER110C; VEuPathDB:YER110C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YRB4
    Summary
    Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in NLS-bearing protein import into nucleus and regulation of pseudohyphal growth. Located in cytoplasm and nucleus. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KAP123 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (378762..382103, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene RNA export factor GLE2 Neighboring gene pseudo Neighboring gene SBF complex DNA-binding subunit SWI4 Neighboring gene U6 snRNA complex subunit LSM4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The identification of protein-protein interactions of the nuclear pore complex of Saccharomyces cerevisiae using high throughput matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry. Huang L, et al. Mol Cell Proteomics, 2002 Jun. PMID 12169684
    2. Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase. Audhya A, et al. EMBO J, 2003 Aug 15. PMID 12912920, Free PMC Article
    3. Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus. Glowczewski L, et al. Mol Cell Biol, 2004 Dec. PMID 15542829, Free PMC Article
    4. Simple kinetic relationships and nonspecific competition govern nuclear import rates in vivo. Timney BL, et al. J Cell Biol, 2006 Nov 20. PMID 17116750, Free PMC Article
    5. Overexpression of yeast karyopherin Pse1p/Kap121p stimulates the mitochondrial import of hydrophobic proteins in vivo. Corral-Debrinski M, et al. Mol Microbiol, 1999 Mar. PMID 10200968

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suppressors of mRNA Decapping Defects Restore Growth Without Major Effects on mRNA Decay Rates or Abundance.
      Title: Suppressors of mRNA Decapping Defects Restore Growth Without Major Effects on mRNA Decay Rates or Abundance.
    2. combined impairment of lipid and Kap123 binding affects targeting of Pom33 to NPCs. These data highlight the requirement of multiple determinants and mechanisms for proper NPC localization of Pom33.
      Title: Nuclear pore targeting of the yeast Pom33 nucleoporin depends on karyopherin and lipid binding.
    3. The karyopherin Kap123 binds to a nuclear localization sequence next to this amphipathic alpha-helix and prevents unspecific tethering of Nbp1 to membranes.
      Title: Targeting of Nbp1 to the inner nuclear membrane is essential for spindle pole body duplication.
    4. Slt2, the mitogen-activated protein kinase of the protein kinase C cell integrity pathway, is constitutively activated in the absence of Kap123, which is consistent with the existence of cell integrity defects.
      Title: Yeast karyopherins Kap123 and Kap95 are related to the function of the cell integrity pathway.
    5. A role for the karyopherin Kap123p in microtubule stability is reported.
      Title: A role for the karyopherin Kap123p in microtubule stability.
    6. Cac1p and Kap123 cooperate to ensure that only appropriately acetylated histone H4 proteins are imported into the nucleus
      Title: Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.
    7. The Kap123p specifically binds to histones H2A and H2B.
      Title: The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    karyopherin KAP123
    NP_011035.1
    • Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      378762..382103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179000.1 → NP_011035.1  TPA: karyopherin KAP123 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011035.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM16, P40069
      UniProtKB/TrEMBL
      A6ZR65, B3LRM6, B5VHN5, C8Z7C8, G2WD14
      Conserved Domains (2) summary
      smart00913
      Location:25 → 92
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:352 → 385
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40069.1

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