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    Gng8 guanine nucleotide binding protein (G protein), gamma 8 [ Mus musculus (house mouse) ]

    Gene ID: 14709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gng8provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), gamma 8provided by MGI
    Primary source
    MGI:MGI:109163
    See related
    Ensembl:ENSMUSG00000063594 AllianceGenome:MGI:109163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg3e; G(y)8
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Acts upstream of or within cellular response to pheromone; nose development; and social behavior. Predicted to be part of heterotrimeric G-protein complex. Is expressed in cochlear duct epithelium; retina; and spleen. Orthologous to human GNG8 (G protein subunit gamma 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 8.7), CNS E11.5 (RPKM 5.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gng8 in Genome Data Viewer
    Location:
    7 A2; 7 9.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16625687..16629361)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16891737..16895451)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330104G04 gene Neighboring gene STARR-positive B cell enhancer ABC_E3701 Neighboring gene STARR-positive B cell enhancer ABC_E443 Neighboring gene dishevelled-binding antagonist of beta-catenin 3 Neighboring gene prostaglandin I receptor (IP) Neighboring gene calmodulin 3 Neighboring gene predicted gene, 45972

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. Montani G, et al. J Physiol, 2013 Aug 15. PMID 23836683, Free PMC Article
    2. Ric-8B interacts with G alpha olf and G gamma 13 and co-localizes with G alpha olf, G beta 1 and G gamma 13 in the cilia of olfactory sensory neurons. Kerr DS, et al. Mol Cell Neurosci, 2008 Jul. PMID 18462949
    3. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. Hurowitz EH, et al. DNA Res, 2000 Apr 28. PMID 10819326
    4. Alteration of Nrp1 signaling at different stages of olfactory neuron maturation promotes glomerular shifts along distinct axes in the olfactory bulb. Assens A, et al. Development, 2016 Oct 15. PMID 27578798, Free PMC Article
    5. Characterization of the development of the mouse cochlear epithelium at the single cell level. Kolla L, et al. Nat Commun, 2020 May 13. PMID 32404924, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nose development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Names
    gamma-9
    guanine nucleotide binding protein (G protein), gamma 8 subunit
    heterotrimeric guanine nucleotide-binding protein 3e

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412471.1 → NP_001399400.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      Status: VALIDATED

      Source sequence(s)
      AC148981
      UniProtKB/Swiss-Prot
      P43426, P63078
      UniProtKB/TrEMBL
      Q3UMY0
      Related
      ENSMUSP00000145533.2, ENSMUST00000205459.2

    2. NM_001412472.1 → NP_001399401.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      Status: VALIDATED

      Source sequence(s)
      AC148981
      UniProtKB/Swiss-Prot
      P43426, P63078
      UniProtKB/TrEMBL
      Q3UMY0
      Related
      ENSMUSP00000145567.2, ENSMUST00000205716.2

    3. NM_001412473.1 → NP_001399402.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      Status: VALIDATED

      Source sequence(s)
      AC148981
      UniProtKB/Swiss-Prot
      P43426, P63078
      UniProtKB/TrEMBL
      Q3UMY0

    4. NM_001412474.1 → NP_001399403.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      Status: VALIDATED

      Source sequence(s)
      AC148981
      UniProtKB/Swiss-Prot
      P43426, P63078
      UniProtKB/TrEMBL
      Q3UMY0

    5. NM_001412475.1 → NP_001399404.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      Status: VALIDATED

      Source sequence(s)
      AC148981
      UniProtKB/Swiss-Prot
      P43426, P63078
      UniProtKB/TrEMBL
      Q3UMY0

    6. NM_001412476.1 → NP_001399405.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      Status: VALIDATED

      Source sequence(s)
      AC148981
      UniProtKB/Swiss-Prot
      P43426, P63078
      UniProtKB/TrEMBL
      Q3UMY0

    7. NM_001412477.1 → NP_001399406.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      Status: VALIDATED

      Source sequence(s)
      AC148981
      UniProtKB/Swiss-Prot
      P43426, P63078
      UniProtKB/TrEMBL
      Q3UMY0

    8. NM_010320.4 → NP_034450.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      See identical proteins and their annotated locations for NP_034450.1

      Status: VALIDATED

      Source sequence(s)
      AC148981
      Consensus CDS
      CCDS20856.1
      UniProtKB/Swiss-Prot
      P43426, P63078
      UniProtKB/TrEMBL
      Q3UMY0
      Related
      ENSMUSP00000077314.5, ENSMUST00000078182.6
      Conserved Domains (1) summary
      smart00224
      Location:8 → 70
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      16625687..16629361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63078.1 GenPept UniProtKB/Swiss-Prot:P63078

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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