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    Etaa1 Ewing tumor-associated antigen 1 [ Mus musculus (house mouse) ]

    Gene ID: 68145, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Etaa1provided by MGI
    Official Full Name
    Ewing tumor-associated antigen 1provided by MGI
    Primary source
    MGI:MGI:1915395
    See related
    Ensembl:ENSMUSG00000016984 AllianceGenome:MGI:1915395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730466H23Rik
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of cell cycle phase transition; and replication fork processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nuclear replication fork. Orthologous to human ETAA1 (ETAA1 activator of ATR kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.4), liver E14 (RPKM 3.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Etaa1 in Genome Data Viewer
    Location:
    11 A3.1; 11 10.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (17888753..17903875, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (17938753..17953875, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28707 Neighboring gene predicted gene, 31268 Neighboring gene VISTA enhancer mm1290 Neighboring gene STARR-seq mESC enhancer starr_28709 Neighboring gene STARR-seq mESC enhancer starr_28710 Neighboring gene STARR-seq mESC enhancer starr_28711 Neighboring gene vacuolar protein sorting 29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28712 Neighboring gene STARR-seq mESC enhancer starr_28715 Neighboring gene STARR-seq mESC enhancer starr_28716 Neighboring gene STARR-seq mESC enhancer starr_28717 Neighboring gene STARR-seq mESC enhancer starr_28718 Neighboring gene STARR-seq mESC enhancer starr_28719 Neighboring gene STARR-seq mESC enhancer starr_28720 Neighboring gene STARR-positive B cell enhancer ABC_E6954 Neighboring gene STARR-seq mESC enhancer starr_28722 Neighboring gene Ewing tumor-associated antigen 1, opposite strand Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion. Miosge LA, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28607084, Free PMC Article
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic G2/M transition checkpoint IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic G2/M transition checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA damage checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ewing's tumor-associated antigen 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362970.1 → NP_001349899.1  ewing's tumor-associated antigen 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK034138, AL627070
      Conserved Domains (1) summary
      pfam15350
      Location:1 → 712
      ETAA1; Ewing's tumor-associated antigen 1 homolog

    2. NM_026576.4 → NP_080852.2  ewing's tumor-associated antigen 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_080852.2

      Status: VALIDATED

      Source sequence(s)
      AK018594, AK019965, AL627070
      Consensus CDS
      CCDS24452.1
      UniProtKB/Swiss-Prot
      Q5SVT3, Q8BZM6, Q8K332, Q9CS19, Q9D2Z9
      Related
      ENSMUSP00000075957.7, ENSMUST00000076661.7
      Conserved Domains (1) summary
      pfam15350
      Location:79 → 865
      ETAA1; Ewing's tumour-associated antigen 1 homologue

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      17888753..17903875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SVT3.1 GenPept UniProtKB/Swiss-Prot:Q5SVT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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