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    Dad1 defender against cell death 1 [ Mus musculus (house mouse) ]

    Gene ID: 13135, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dad1provided by MGI
    Official Full Name
    defender against cell death 1provided by MGI
    Primary source
    MGI:MGI:101912
    See related
    Ensembl:ENSMUSG00000022174 AllianceGenome:MGI:101912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable enzyme activator activity. Acts upstream of or within blastocyst development and negative regulation of apoptotic process. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 143.6), duodenum adult (RPKM 96.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dad1 in Genome Data Viewer
    Location:
    14 C2; 14 27.7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54472942..54491386, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54235485..54253929, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha chain Neighboring gene STARR-positive B cell enhancer ABC_E7311 Neighboring gene CapStarr-seq enhancers MGSCv37_chr14:54846812-54847013 and MGSCv37_chr14:54847102-54847395 Neighboring gene STARR-positive B cell enhancer ABC_E5435 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:54852981-54853251 Neighboring gene STARR-positive B cell enhancer ABC_E1168 Neighboring gene T cell receptor alpha joining 1 Neighboring gene abhydrolase domain containing 4 Neighboring gene olfactory receptor family 6 subfamily E member 1 Neighboring gene T cell receptor alpha constant

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues. Ortiz BD, et al. EMBO J, 1997 Aug 15. PMID 9305645, Free PMC Article
    2. Abnormalities of developmental cell death in Dad1-deficient mice. Nishii K, et al. Genes Cells, 1999 Apr. PMID 10336695
    3. Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus. Ortiz BD, et al. J Immunol, 2001 Oct 1. PMID 11564801
    4. A highly conserved apoptotic suppressor gene is located near the chicken T-cell receptor alpha chain constant region. Wang K, et al. Immunogenetics, 1997. PMID 9271627
    5. Deletion of Dad1 in mice induces an apoptosis-associated embryonic death. Brewster JL, et al. Genesis, 2000 Apr. PMID 10748466

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oligosaccharyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oligosaccharyltransferase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
    Names
    DAD-1
    oligosaccharyl transferase subunit DAD1
    NP_001106829.1
    NP_034145.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113358.1 → NP_001106829.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

      See identical proteins and their annotated locations for NP_001106829.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK002446, BC058116, CN833883
      Consensus CDS
      CCDS27084.1
      UniProtKB/Swiss-Prot
      P61804, Q3V3W6
      Related
      ENSMUSP00000022781.8, ENSMUST00000022781.8
      Conserved Domains (1) summary
      pfam02109
      Location:7 → 113
      DAD; DAD family

    2. NM_010015.4 → NP_034145.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

      See identical proteins and their annotated locations for NP_034145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing the 3' terminal non-coding exon found in transcript variant 1, therefore, has a different 3' UTR. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK030925, CN833883
      Consensus CDS
      CCDS27084.1
      UniProtKB/Swiss-Prot
      P61804, Q3V3W6
      Related
      ENSMUSP00000122366.2, ENSMUST00000128231.2
      Conserved Domains (1) summary
      pfam02109
      Location:7 → 113
      DAD; DAD family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54472942..54491386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61804.3 GenPept UniProtKB/Swiss-Prot:P61804

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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