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    EHT1 medium-chain fatty acid ethyl ester synthase/esterase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EHT1
    Official Full Name
    medium-chain fatty acid ethyl ester synthase/esterase
    Primary source
    SGD:S000000381
    Locus tag
    YBR177C
    See related
    AllianceGenome:SGD:S000000381; FungiDB:YBR177C; VEuPathDB:YBR177C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alcohol O-acetyltransferase activity and short-chain carboxylesterase activity. Involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Located in lipid droplet. Orthologous to several human genes including ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EHT1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (584807..586162, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Swd3p Neighboring gene 3-methyl-2-oxobutanoate hydroxymethyltransferase Neighboring gene mitofusin Neighboring gene Dtr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast enzyme Eht1 is an octanoyl-CoA:ethanol acyltransferase that also functions as a thioesterase. Knight MJ, et al. Yeast, 2014 Dec. PMID 25308280, Free PMC Article
    2. Controlled intracellular trafficking alleviates an expression bottleneck in S. cerevisiae ester biosynthesis. Zhu J, et al. Metab Eng Commun, 2019 Jun. PMID 30622894, Free PMC Article
    3. Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation. Yang X, et al. J Microbiol Biotechnol, 2022 Jun 28. PMID 35484971, Free PMC Article
    4. Parameters affecting ethyl ester production by Saccharomyces cerevisiae during fermentation. Saerens SM, et al. Appl Environ Microbiol, 2008 Jan. PMID 17993562, Free PMC Article
    5. Enhanced ethyl caproate production of Chinese liquor yeast by overexpressing EHT1 with deleted FAA1. Chen Y, et al. J Ind Microbiol Biotechnol, 2014 Mar. PMID 24370880

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation.
      Title: Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation.
    2. The Saccharomyces cerevisiae gene YBR177C/EHT1 should thus be reannotated as coding for an octanoyl-CoA:ethanol acyltransferase that can also function as a thioesterase.
      Title: The yeast enzyme Eht1 is an octanoyl-CoA:ethanol acyltransferase that also functions as a thioesterase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    enables short-chain carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in medium-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in medium-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    medium-chain fatty acid ethyl ester synthase/esterase
    NP_009736.3
    • Octanoyl-CoA:ethanol acyltransferase; also functions as thioesterase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      584807..586162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178525.3 → NP_009736.3  TPA: medium-chain fatty acid ethyl ester synthase/esterase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009736.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQH2, P38295
      UniProtKB/TrEMBL
      E9P8C9, G2W9H9, N1P9J4
      Conserved Domains (1) summary
      COG0429
      Location:38 → 451
      YheT; Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38295.1

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