MLC2 Mlc2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MLC2
Official Full Name: Mlc2p
Primary source: SGD:S000006392
Locus tag: YPR188C
See related: AllianceGenome:SGD:S000006392; FungiDB:YPR188C; VEuPathDB:YPR188C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables myosin II heavy chain binding activity. Involved in mitotic actomyosin contractile ring contraction. Located in cellular bud neck contractile ring and incipient cellular bud site. Part of myosin II complex. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to several human genes including MYL12A (myosin light chain 12A); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MLC2 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (911988..912479, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo1p is the first example of a myosin whose cellular function does not require a catalytic motor domain revealing a novel mechanism of action for budding yeast myosin-II independent of actin binding and ATPase activity.
Title: Cytokinesis depends on the motor domains of myosin-II in fission yeast but not in budding yeast.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin II heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic actomyosin contractile ring contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mlc2p

NP_015514.1

Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

911988..912479 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184285.1 → NP_015514.1 TPA: Mlc2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015514.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4I8, Q06580

UniProtKB/TrEMBL

B3LKE7, C7GP69, C8ZJL7, G2WPZ9, N1NVM6

Conserved Domains (1) summary

COG5126
Location:4 → 163

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]