Sprr1b small proline-rich protein 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sprr1bprovided by MGI
Official Full Name: small proline-rich protein 1Bprovided by MGI
Primary source: MGI:MGI:106659
See related: Ensembl:ENSMUSG00000048455 AllianceGenome:MGI:106659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cytoskeleton organization and keratinization. Predicted to act upstream of or within regulation of cell shape. Predicted to be located in Golgi apparatus; cornified envelope; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; skin; and thymus. Orthologous to several human genes including SPRR3 (small proline rich protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 12.9), lung adult (RPKM 9.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (92344115..92346124, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92436808..92438817, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPRR1B expression pattern in nonsquamous tumors; findings indicate SPRR1B likely coupled to signals responsible for withdrawal from the proliferative state; overexpression for prolonged periods may disrupt normal progression of mitosis
Title: SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492890

Sprr1b (e-PCR), detects polymorphism
- UniSTS:547471

X91825 (e-PCR)
- UniSTS:125885

X91825 (e-PCR)
- UniSTS:185552

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in keratinization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell shape	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cornified envelope	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cornifin-B

Names: SPR1 B; SPR1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.