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    RSE1 U2 snRNP complex subunit RSE1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSE1
    Official Full Name
    U2 snRNP complex subunit RSE1
    Primary source
    SGD:S000004513
    Locus tag
    YML049C
    See related
    AllianceGenome:SGD:S000004513; FungiDB:YML049C; VEuPathDB:YML049C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U2 snRNA binding activity. Involved in spliceosomal complex assembly. Part of U2 snRNP and U2-type prespliceosome. Orthologous to human SF3B3 (splicing factor 3b subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RSE1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (174220..178305, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene transcription regulator GAL80 Neighboring gene Aim32p Neighboring gene Gsf2p Neighboring gene pheromone-regulated K(+) transporter PRM6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PSI-BLAST searches using hidden markov models of structural repeats: prediction of an unusual sliding DNA clamp and of beta-propellers in UV-damaged DNA-binding protein. Neuwald AF, et al. Nucleic Acids Res, 2000 Sep 15. PMID 10982878, Free PMC Article
    2. A link between secretion and pre-mRNA processing defects in Saccharomyces cerevisiae and the identification of a novel splicing gene, RSE1. Chen EJ, et al. Mol Cell Biol, 1998 Dec. PMID 9819400, Free PMC Article
    3. Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly. Caspary F, et al. EMBO J, 1999 Jun 15. PMID 10369685, Free PMC Article
    4. Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Das BK, et al. Mol Cell Biol, 1999 Oct. PMID 10490618, Free PMC Article
    5. Rds3p is required for stable U2 snRNP recruitment to the splicing apparatus. Wang Q, et al. Mol Cell Biol, 2003 Oct. PMID 14517302, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables U2 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U2 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP complex subunit RSE1
    NP_013663.1
    • Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      174220..178305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182407.1 → NP_013663.1  TPA: U2 snRNP complex subunit RSE1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013663.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZC6, Q04693
      UniProtKB/TrEMBL
      A6ZM18, B3LLK8, C7GS65
      Conserved Domains (2) summary
      pfam03178
      Location:1002 → 1328
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:147 → 673
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04693.1

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