Zbtb22 zinc finger and BTB domain containing 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb22provided by MGI
Official Full Name: zinc finger and BTB domain containing 22provided by MGI
Primary source: MGI:MGI:1931870
See related: Ensembl:ENSMUSG00000051390 AllianceGenome:MGI:1931870
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bing1; Zfp297; 1110008J20Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human ZBTB22 (zinc finger and BTB domain containing 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 44.7), ovary adult (RPKM 43.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34135150..34138299)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33916176..33919325)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1-driven gluconeogenesis.
Title: Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1-driven gluconeogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI415166 (e-PCR)
- UniSTS:181004

UniSTS:237624 (e-PCR)
- UniSTS:237624

Zfp297 (e-PCR), detects polymorphism
- UniSTS:463439

AI265210 (e-PCR)
- UniSTS:160652

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 22

Names: zinc finger protein 297

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020625.3 → NP_065650.1 zinc finger and BTB domain-containing protein 22

See identical proteins and their annotated locations for NP_065650.1

Status: VALIDATED

Source sequence(s)

BC052154, BY011334

Consensus CDS

CCDS28634.1

UniProtKB/Swiss-Prot

Q9Z0G7

UniProtKB/TrEMBL

Q3TW94, Q3TXW4

Related

ENSMUSP00000057466.10, ENSMUST00000053429.11

Conserved Domains (5) summary

smart00225
Location:58 → 147

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:485 → 504

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:510 → 532

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:47 → 147

BTB; BTB/POZ domain

pfam13465
Location:524 → 547

zf-H2C2_2; Zinc-finger double domain