Spata13 spermatogenesis associated 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spata13provided by MGI
Official Full Name: spermatogenesis associated 13provided by MGI
Primary source: MGI:MGI:104838
See related: Ensembl:ENSMUSG00000021990 AllianceGenome:MGI:104838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: asef2; ESTM11; mFLJ00298
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Located in podosome. Is expressed in brain; liver; testis; thymus primordium; and vertebral cartilage condensation. Orthologous to human SPATA13 (spermatogenesis associated 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 11.9), adrenal adult (RPKM 5.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 31.77 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (60722617..61002005)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (60485168..60764556)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spata13 modulates social hierarchy in both male and female mice in addition to affecting voluntary activity in females.
Title: The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity.
Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. [Asef2, mouse]
Title: The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126490 (e-PCR)
- UniSTS:163198

NoName (e-PCR)
- UniSTS:237200

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: spermatogenesis-associated protein 13

Names: APC-stimulated guanine nucleotide exchange factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033272.3 → NP_001028444.1 spermatogenesis-associated protein 13 isoform 1

See identical proteins and their annotated locations for NP_001028444.1

Status: VALIDATED

Source sequence(s)

AC114000, AC151835

Consensus CDS

CCDS49516.1

UniProtKB/TrEMBL

B9EHV2, E9Q3I3

Related

ENSMUSP00000022566.8, ENSMUST00000022566.14

Conserved Domains (4) summary

cd11973
Location:726 → 797

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:836 → 1015

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:200 → 446

PHA03247; large tegument protein UL36; Provisional

cd01224
Location:1020 → 1158

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
NM_001310594.2 → NP_001297523.1 spermatogenesis-associated protein 13 isoform 2

Status: VALIDATED

Source sequence(s)

AC114000, AC151835

Consensus CDS

CCDS79328.1

UniProtKB/Swiss-Prot

Q3TZ09, Q5DU57

UniProtKB/TrEMBL

B7ZNJ6, E0CYU0

Related

ENSMUSP00000123888.2, ENSMUST00000162945.2

Conserved Domains (4) summary

cd11973
Location:56 → 127

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

cd01224
Location:350 → 488

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

pfam00169
Location:378 → 477

PH; PH domain

pfam00621
Location:166 → 345

RhoGEF; RhoGEF domain
NM_001404949.1 → NP_001391878.1 spermatogenesis-associated protein 13 isoform 3

Status: VALIDATED

Source sequence(s)

AC114000, AC151835, AC164429
NM_001404950.1 → NP_001391879.1 spermatogenesis-associated protein 13 isoform 3

Status: VALIDATED

Source sequence(s)

AC114000, AC151835
NM_001404951.1 → NP_001391880.1 spermatogenesis-associated protein 13 isoform 3

Status: VALIDATED

Source sequence(s)

AC114000, AC151835
NM_001404952.1 → NP_001391881.1 spermatogenesis-associated protein 13 isoform 4

Status: VALIDATED

Source sequence(s)

AC114000, AC151835
NM_001404953.1 → NP_001391882.1 spermatogenesis-associated protein 13 isoform 5

Status: VALIDATED

Source sequence(s)

AC114000, AC151835
NM_001404954.1 → NP_001391883.1 spermatogenesis-associated protein 13 isoform 6

Status: VALIDATED

Source sequence(s)

AC114000, AC151835
NM_001404964.1 → NP_001391893.1 spermatogenesis-associated protein 13 isoform 1

Status: VALIDATED

Source sequence(s)

AC114000, AC151835

UniProtKB/TrEMBL

E9Q3I3

Related

ENSMUSP00000123928.2, ENSMUST00000160973.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

60722617..61002005

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247763.1 → XP_030103623.1 spermatogenesis-associated protein 13 isoform X3

UniProtKB/TrEMBL

B9EHV2, E9Q3I3

Conserved Domains (4) summary

cd11973
Location:726 → 797

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:836 → 1015

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:200 → 446

PHA03247; large tegument protein UL36; Provisional

cd01224
Location:1020 → 1158

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
XM_017315974.3 → XP_017171463.1 spermatogenesis-associated protein 13 isoform X8

Conserved Domains (1) summary

PHA03247
Location:251 → 497

PHA03247; large tegument protein UL36; Provisional
XM_036158561.1 → XP_036014454.1 spermatogenesis-associated protein 13 isoform X1

UniProtKB/TrEMBL

B9EHV2

Conserved Domains (4) summary

cd11973
Location:777 → 848

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:887 → 1066

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:251 → 497

PHA03247; large tegument protein UL36; Provisional

cd01224
Location:1071 → 1209

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
XM_036158562.1 → XP_036014455.1 spermatogenesis-associated protein 13 isoform X2

UniProtKB/TrEMBL

B9EHV2

Conserved Domains (4) summary

cd11973
Location:767 → 838

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:877 → 1056

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:251 → 500

PHA03247; large tegument protein UL36; Provisional

cd01224
Location:1061 → 1199

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
XM_036158565.1 → XP_036014458.1 spermatogenesis-associated protein 13 isoform X5

UniProtKB/TrEMBL

B9EHV2

Conserved Domains (4) summary

cd11973
Location:655 → 726

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:765 → 944

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:251 → 603

PHA03247; large tegument protein UL36; Provisional

cd01224
Location:949 → 1087

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
XM_011245026.3 → XP_011243328.1 spermatogenesis-associated protein 13 isoform X3

See identical proteins and their annotated locations for XP_011243328.1

UniProtKB/TrEMBL

B9EHV2, E9Q3I3

Conserved Domains (4) summary

cd11973
Location:726 → 797

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:836 → 1015

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:200 → 446

PHA03247; large tegument protein UL36; Provisional

cd01224
Location:1020 → 1158

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
XM_030247762.1 → XP_030103622.1 spermatogenesis-associated protein 13 isoform X3

UniProtKB/TrEMBL

B9EHV2, E9Q3I3

Conserved Domains (4) summary

cd11973
Location:726 → 797

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:836 → 1015

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:200 → 446

PHA03247; large tegument protein UL36; Provisional

cd01224
Location:1020 → 1158

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
XM_030247764.1 → XP_030103624.1 spermatogenesis-associated protein 13 isoform X3

UniProtKB/TrEMBL

B9EHV2, E9Q3I3

Conserved Domains (4) summary

cd11973
Location:726 → 797

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:836 → 1015

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:200 → 446

PHA03247; large tegument protein UL36; Provisional

cd01224
Location:1020 → 1158

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
XM_006518870.3 → XP_006518933.1 spermatogenesis-associated protein 13 isoform X7

UniProtKB/Swiss-Prot

Q3TZ09, Q5DU57

Conserved Domains (3) summary

cd11973
Location:231 → 302

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

smart00325
Location:341 → 520

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01224
Location:525 → 663

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain