S100b S100 protein, beta polypeptide, neural [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100bprovided by MGI
Official Full Name: S100 protein, beta polypeptide, neuralprovided by MGI
Primary source: MGI:MGI:98217
See related: Ensembl:ENSMUSG00000033208 AllianceGenome:MGI:98217
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bpb
Summary: Predicted to enable several functions, including RAGE receptor binding activity; S100 protein binding activity; and metal ion binding activity. Involved in several processes, including adaptive thermogenesis; positive regulation of neuron differentiation; and sympathetic neuron projection extension. Acts upstream of or within memory and regulation of neuronal synaptic plasticity. Located in cytoplasm; neuronal cell body; and nucleus. Is active in extracellular region. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 164.7), frontal lobe adult (RPKM 54.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.76 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (76089670..76097153)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (76253836..76261319)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocyte S100beta expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model.
Title: Astrocyte S100β expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model.
Neuroanatomical and morphometric study of S100beta positive astrocytes in the entorhinal cortex during ageing in the 3xTg-Alzehimer's disease mouse model.
Title: Neuroanatomical and morphometric study of S100β positive astrocytes in the entorhinal cortex during ageing in the 3xTg-Alzehimer's disease mouse model.
CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells.
Title: CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells.
S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS.
Title: S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS.
S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.
Title: S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.
Characterization of cell type-specific S100B expression in the mouse olfactory bulb.
Title: Characterization of cell type-specific S100B expression in the mouse olfactory bulb.
Implications of increased S100beta and Tau5 proteins in dystrophic nerves of two mdx mouse models for Duchenne muscular dystrophy.
Title: Implications of increased S100β and Tau5 proteins in dystrophic nerves of two mdx mouse models for Duchenne muscular dystrophy.
A deficiency of S100b phenocopies deficiency of calsyntenin 3beta, and forced expression of S100b in brown adipocytes rescues the defective sympathetic innervation that is caused by ablation of calsyntenin 3beta; data reveal a mammal-specific mechanism of communication between thermogenic adipocytes and sympathetic neurons
Title: Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis.
Findings indicate the role of S100B in gliomagenesis and suggest the development of more potent S100B inhibitors for glioma therapy.
Title: S100B suppression alters polarization of infiltrating myeloid-derived cells in gliomas and inhibits tumor growth.
levels of S100B differentially affect skeletal muscle repair upon acute injury and in the context of muscular dystrophy, and S100B might be regarded as a potential molecular target in Duchenne muscular dystrophy .
Title: Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224308

S100b (e-PCR), detects polymorphism
- UniSTS:259138

AI850290 (e-PCR), detects polymorphism
- UniSTS:180057

AI850290 (e-PCR), detects polymorphism
- UniSTS:259583

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RAGE receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables RAGE receptor binding	IEA Inferred from Electronic Annotation more info
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables S100 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables S100 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in energy reserve metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular calcium ion homeostasis	NAS Non-traceable Author Statement more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic neuron projection extension	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-B

Names: S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009115.3 → NP_033141.1 protein S100-B

See identical proteins and their annotated locations for NP_033141.1

Status: VALIDATED

Source sequence(s)

AK135083, AW456919, BC061178, CX205737

Consensus CDS

CCDS35943.1

UniProtKB/Swiss-Prot

P50114

UniProtKB/TrEMBL

Q3UY00

Related

ENSMUSP00000047968.8, ENSMUST00000036387.8

Conserved Domains (2) summary

cd05027
Location:2 → 89

S-100B; S-100B: S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

pfam13499
Location:27 → 78

EF-hand_7; EF-hand domain pair